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CRISPR-based electrochemical biosensors for animal health: Recent advances.
Gattani, Anil; Mandal, Sanju; Agrawal, Aditya; Patel, Pragati; Jain, Anand Kumar; Singh, Purnima; Garg, Akshay; Mishra, Aditya.
Afiliación
  • Gattani A; Department of Veterinary Physiology and Biochemistry, College of Veterinary Science and Animal Husbandry, NDVSU, Jabalpur, India. Electronic address: gattanianil@gmail.com.
  • Mandal S; Department of Veterinary Physiology and Biochemistry, College of Veterinary Science and Animal Husbandry, NDVSU, Jabalpur, India.
  • Agrawal A; Department of Veterinary Physiology and Biochemistry, College of Veterinary Science and Animal Husbandry, Rewa, India.
  • Patel P; Department of Veterinary Physiology and Biochemistry, College of Veterinary Science and Animal Husbandry, NDVSU, Jabalpur, India.
  • Jain AK; Department of Veterinary Physiology and Biochemistry, College of Veterinary Science and Animal Husbandry, NDVSU, Jabalpur, India.
  • Singh P; Department of Veterinary Physiology and Biochemistry, College of Veterinary Science and Animal Husbandry, NDVSU, Jabalpur, India.
  • Garg A; Directorate of Research Services, NDVSU, Jabalpur, India.
  • Mishra A; Department of Veterinary Physiology and Biochemistry, College of Veterinary Science and Animal Husbandry, NDVSU, Jabalpur, India.
Prog Biophys Mol Biol ; 193: 7-18, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39237013
ABSTRACT
Animal diseases are a major concern to animal welfare, human health and the global economy. Early detection, prevention and control of these animal diseases are crucial to ensure sustainability of livestock sector, to reduce farm losses and protecting public health. Points of care (POC) devices are small, portable instruments that provide rapid results thus reduce the risk of disease transmission and enable early intervention. CRISPR based diagnostics offer more accurate and efficient solution for monitoring animal health due to their quick response, can detect very low level of pathogenic organism or disease markers and specificity. These diagnostics are particularly useful in the in area with limited resources or access to common diagnostic methods, especially in developing countries. The ability of electrochemical sensors to detect accurately very low analyte concentration makes them suitable for POC diagnostics and field application. CRISPR base electrochemical biosensors show great potential in revolutionizing disease detection and diagnosis including animal health. However, challenges, such as achieving selectivity and sensitivity, need to be addressed to enhance the competitiveness of these biosensors. Currently, most CRISPR based bioassay research focuses on nucleic acid target detection, but researchers exploring to monitor small organic/inorganic non-nucleic acid molecules like toxins and proteins. Emerging diagnostics would be centered on CRISPR-Cas system will offer great potential as an accurate, specific and effective means to identify microorganism, virus, toxins, small molecules, peptides and nucleic acid related to various animal health disorders particularly when integrated into electrochemical biosensing platform.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas Biosensibles Límite: Animals Idioma: En Revista: Prog Biophys Mol Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas Biosensibles Límite: Animals Idioma: En Revista: Prog Biophys Mol Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido