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Biofilm formation, antibiotic-resistance and clonal relatedness among clinical isolates of Acinetobacterbaumannii.
Aramli, Nima; Safarkar, Roya; Shiralipour, Aref; Sadeghi, Zahra.
Afiliación
  • Aramli N; Department of Biology, Islamic Azad University, Ardabil Branch, Ardabil, Iran. Electronic address: aramli.nima@gmail.com.
  • Safarkar R; Department of Biology, Islamic Azad University, Ardabil Branch, Ardabil, Iran.
  • Shiralipour A; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Sadeghi Z; Laboratory of Alavi Educational Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
Microb Pathog ; 195: 106916, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39236969
ABSTRACT
In this work, the antibiotic resistance, biofilm formation capability, and clonal relatedness of 50 A. baumannii isolates collected from three hospitals in Ardabil city, Iran, were evaluated. Antibiotic sensitivity and biofilm formation of isolates were determined by disk diffusion and microtiter-plate methods, respectively. Molecular typing of isolates was also performed using repetitive sequence-based PCR (REP-PCR). The majority of isolates were resistant to cephems, aminoglycosides, and carbapenems, with 80 % classified as multi-drug resistant (MDR). While, only isolates collected from blood and tracheal were resistant to colistin. Additionally, 42 isolates (84 %) had biofilm formation capability. According to rep-PCR results, 34 isolates showed similar banding patterns, while 16 isolates had unique banding patterns. Finally, based on the molecular analysis, there was a direct relationship between biofilm formation and the antibiotic resistance of isolates. In other words, MDR isolates had a higher ability to form biofilm.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Acinetobacter / Pruebas de Sensibilidad Microbiana / Biopelículas / Farmacorresistencia Bacteriana Múltiple / Acinetobacter baumannii / Antibacterianos Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Acinetobacter / Pruebas de Sensibilidad Microbiana / Biopelículas / Farmacorresistencia Bacteriana Múltiple / Acinetobacter baumannii / Antibacterianos Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido