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The role of thyroid-stimulating hormone in regulating lipid metabolism: Implications for body-brain communication.
Wang, Xueqin; Wu, Zhen; Liu, Yuting; Wu, Chengxi; Jiang, Jun; Hashimoto, Kenji; Zhou, Xiangyu.
Afiliación
  • Wang X; Department of Thyroid Surgery, Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Wu Z; Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Liu Y; Department of Thyroid Surgery, Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Wu C; Department of Thyroid Surgery, Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Jiang J; Department of Thyroid Surgery, Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Hashimoto K; Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan.
  • Zhou X; Department of Thyroid Surgery, Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: zhouxiangyu@swmu.edu.cn.
Neurobiol Dis ; 201: 106658, 2024 Oct 15.
Article en En | MEDLINE | ID: mdl-39236910
ABSTRACT
Thyroid-stimulating hormone (TSH) is a pituitary hormone that stimulates the thyroid gland to produce and release thyroid hormones, primarily thyroxine and triiodothyronine. These hormones are key players in body-brain communication, influencing various physiological processes, including the regulation of metabolism (both peripheral and central effects), feedback mechanisms, and lipid metabolism. Recently, the increasing incidence of abnormal lipid metabolism has highlighted the link between thyroid function and lipid metabolism. Evidence suggests that TSH can affect all bodily systems through body-brain communication, playing a crucial role in growth, development, and the regulation of various physiological systems. Lipids serve dual

purposes:

they are involved in energy storage and metabolism, and they act as vital signaling molecules in numerous cellular activities, maintaining overall human health or contributing to various diseases. This article reviews the role of TSH in regulating lipid metabolism via body-brain crosstalk, focusing on its implications for common lipid metabolism disorders such as obesity, atherosclerosis, nonalcoholic fatty liver disease, neuropsychiatric disorders (including Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and depression), and cerebrovascular disorders such as stroke.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Tirotropina / Metabolismo de los Lípidos Límite: Animals / Humans Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Tirotropina / Metabolismo de los Lípidos Límite: Animals / Humans Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos