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Socioeconomic inequalities, genetic susceptibility, and risks of depression and anxiety: A large-observational study.
Qi, Xin; Yang, Jin; Liu, Li; Hao, Jingcan; Pan, Chuyu; Wen, Yan; Zhang, Na; Wei, Wenming; Kang, Meijuan; Cheng, Bolun; Cheng, Shiqiang; Zhang, Feng.
Afiliación
  • Qi X; Precision medicine center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
  • Yang J; Precision medicine center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Department of Medical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
  • Liu L; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
  • Hao J; Medical department, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
  • Pan C; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
  • Wen Y; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
  • Zhang N; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
  • Wei W; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
  • Kang M; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
  • Cheng B; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
  • Cheng S; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China.
  • Zhang F; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, PR China; Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
J Affect Disord ; 367: 174-183, 2024 Dec 15.
Article en En | MEDLINE | ID: mdl-39236878
ABSTRACT

OBJECTIVES:

This study aimed to investigate the interplay between genetic susceptibility and socioeconomic disparities on psychiatric disorders.

METHODS:

In this study, we utilized data from the UK Biobank to analyze the Generalized Anxiety Disorder (GAD)-7 scale (N = 74,425) and the Patient Health Questionnaire (PHQ)-9 (N = 74,101), along with the Index of Multiple Deprivation (IMD). The polygenic risk score (PRS) was calculated to assess the genetic risk associated with GAD-7/PHQ-9 scores, and the individuals were classified into low, medium, and high genetic risk groups according to tertiles of PRSs related to the GAD-7/PHQ-9. Linear regression models were used to explore the relationships between GAD-7/PHQ-9 scores and IMD scores in patients with different genetic susceptibilities.

RESULTS:

Disadvantaged socioeconomic status was associated with the risk of anxiety and depression across all strata of genetic risk, and stronger associations were shown for individuals with greater genetic susceptibility. From low to high genetic risk, the risk of psychiatric disorders increased for the GAD-7 (ß = 0.002 to 0.032) and PHQ-9 (ß = 0.003 to 0.045) scores. In addition, strong associations of high genetic risk with anxiety (ß = 0.875) and depression (ß = 1.152) were detected in the IMD quartile 4 group compared with the least deprivation quartile group. Furthermore, income and employment were estimated to contribute strongly to anxiety (ßemployment = 7.331, ßincome = 4.492) and depression (ßemployment = 9.951, ßincome = 6.453) in the high genetic risk group.

CONCLUSION:

The results suggest that we should pay more attention to psychiatric disorders with high genetic susceptibility and try to improve their socioeconomic status to prevent the development of psychiatric disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Factores Socioeconómicos / Predisposición Genética a la Enfermedad Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Factores Socioeconómicos / Predisposición Genética a la Enfermedad Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos