Your browser doesn't support javascript.
loading
A dendritic cell-recruiting, antimicrobial blood clot hydrogel for melanoma recurrence prevention and infected wound management.
Liu, Wen-Shang; Lu, Zheng-Mao; Pu, Xiao-Hui; Li, Xin-Ying; Zhang, Hui-Qi; Zhang, Zhuan-Zhuan; Zhang, Xin-Yi; Shi, Te; Jiang, Xiang-He; Zhou, Jing-Sheng; Zhou, Xuan; Xin, Zhong-Yuan; Li, Mei-Gui; Yuan, Jing; Chen, Cui-Min; Zhang, Xiao-Wei; Gao, Jie; Li, Meng.
Afiliación
  • Liu WS; Department of Dermatology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, People's Republic of China; School of Pharmacy, Henan University, Kaifeng, 475004, People's Republic of China.
  • Lu ZM; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
  • Pu XH; School of Pharmacy, Henan University, Kaifeng, 475004, People's Republic of China.
  • Li XY; Department of Laboratory & Diagnosis, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
  • Zhang HQ; Department of Dermatology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, People's Republic of China; School of Pharmacy, Henan University, Kaifeng, 475004, People's Republic of China.
  • Zhang ZZ; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, People's Republic of China.
  • Zhang XY; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, People's Republic of China.
  • Shi T; Department of Gastroenterology, People's Liberation Army of China Naval Medical Center, Shanghai, 200052, People's Republic of China.
  • Jiang XH; College of Life Science, Mudanjiang Medical University, Mudanjiang, 157011, People's Republic of China.
  • Zhou JS; College of Life Science, Mudanjiang Medical University, Mudanjiang, 157011, People's Republic of China.
  • Zhou X; School of Pharmacy, Henan University, Kaifeng, 475004, People's Republic of China.
  • Xin ZY; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China.
  • Li MG; School of Pharmacy, Henan University, Kaifeng, 475004, People's Republic of China.
  • Yuan J; Department of Pediatrics, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
  • Chen CM; Changhai Clinical Research Unit, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China.
  • Zhang XW; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, People's Republic of China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China. Electronic address: dongfangzhizizhxw@aliyun.com.
  • Gao J; Changhai Clinical Research Unit, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People's Republic of China. Electronic address: gaojiehighclea@smmu.edu.cn.
  • Li M; Department of Dermatology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, People's Republic of China. Electronic address: lemonlives_dr@163.com.
Biomaterials ; 313: 122776, 2025 Feb.
Article en En | MEDLINE | ID: mdl-39236629
ABSTRACT
Surgical resection, the mainstay for melanoma treatment, faces challenges due to high tumor recurrence rates and complex postoperative wound healing. Chronic inflammation from residual disease and the risk of secondary infections impede healing. We introduce an innovative, injectable hydrogel system that integrates a multifaceted therapeutic approach. The hydrogel, crosslinked by calcium ions with sodium alginate, encapsulates a blood clot rich in dendritic cells (DCs) chemoattractants and melanoma cell-derived nanovesicles (NVs), functioning as a potent immunostimulant. This in situ recruitment strategy overcomes the limitations of subcutaneous tumor vaccine injections and more effectively achieves antitumor immunity. Additionally, the hydrogel incorporates Chlorella extracts, enhancing its antimicrobial properties to prevent wound infections and promote healing. One of the key findings of our research is the dual functionality of Chlorella extracts; they not only expedite the healing process of infected wounds but also increase the hydrogel's ability to stimulate an antitumor immune response. Given the patient-specific nature of the blood clot and NVs, our hydrogel system offers customizable solutions for individual postoperative requirements. This personalized approach is highlighted by our study, which demonstrates the synergistic impact of the composite hydrogel on preventing melanoma recurrence and hastening wound healing, potentially transforming postsurgical melanoma management.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Células Dendríticas / Hidrogeles / Melanoma Límite: Animals / Female / Humans Idioma: En Revista: Biomaterials Año: 2025 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Células Dendríticas / Hidrogeles / Melanoma Límite: Animals / Female / Humans Idioma: En Revista: Biomaterials Año: 2025 Tipo del documento: Article Pais de publicación: Países Bajos