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Chemogenetic inhibition of pain-related neurons in the posterior insula cortex reduces mechanical hyperalgesia and anxiety-like behavior during acute pain.
Potapenko, Ilia Viktorovich; Ishikawa, Tatsuya; Okuda, Hiroaki; Hori, Kiyomi; Ozaki, Noriyuki.
Afiliación
  • Potapenko IV; Department of Functional Anatomy, Graduate School of Medical Sciences, Kanazawa University, Takara-machi, Kanazawa, 920-8640, Japan; Department of Medical and Biological Physics, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Partizan Zheleznyak st. 1, 660022, Krasnoya
  • Ishikawa T; Department of Functional Anatomy, Graduate School of Medical Sciences, Kanazawa University, Takara-machi, Kanazawa, 920-8640, Japan. Electronic address: tishikawa@med.kanazawa-u.ac.jp.
  • Okuda H; Department of Functional Anatomy, Graduate School of Medical Sciences, Kanazawa University, Takara-machi, Kanazawa, 920-8640, Japan.
  • Hori K; Department of Functional Anatomy, Graduate School of Medical Sciences, Kanazawa University, Takara-machi, Kanazawa, 920-8640, Japan.
  • Ozaki N; Department of Functional Anatomy, Graduate School of Medical Sciences, Kanazawa University, Takara-machi, Kanazawa, 920-8640, Japan. Electronic address: nozaki@med.kanazawa-u.ac.jp.
Biochem Biophys Res Commun ; 734: 150625, 2024 Aug 29.
Article en En | MEDLINE | ID: mdl-39236586
ABSTRACT
Pain is a complex phenomenon that involves sensory, emotional, and cognitive components. The posterior insula cortex (pIC) has been shown to integrate multisensory experience with emotional and cognitive states. However, the involvement of the pIC in the regulation of affective behavior in pain remains unclear. Here, we investigate the role of pain-related pIC neurons in the regulation of anxiety-like behavior during acute pain. We combined a chemogenetic approach with targeted recombination in active populations (TRAP) in mice. Global chemogenetic inhibition of pIC neurons attenuates chemically-induced mechanical hypersensitivity without affecting pain-related anxiety-like behavior. In contrast, inhibition of pain-related pIC neurons reduces both mechanical hypersensitivity and pain-related anxiety-like behavior. The present study provides important insights into the role of pIC neurons in the regulation of sensory and affective pain-related behavior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biochem Biophys Res Commun Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biochem Biophys Res Commun Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos