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Comparison of the diagnostic accuracy of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society and American Association of Electrodiagnostic Medicine diagnostic criteria for multifocal motor neuropathy.
Doneddu, Pietro Emiliano; Gallo, Chiara; Gentile, Luca; Cocito, Dario; Falzone, Yuri; Di Stefano, Vincenzo; Inghilleri, Maurizio; Cosentino, Giuseppe; Matà, Sabrina; Mazzeo, Anna; Filosto, Massimiliano; Peci, Erdita; Sorrenti, Benedetta; Brighina, Filippo; Moret, Federica; Vegezzi, Elisa; Sperti, Martina; Risi, Barbara; Nobile-Orazio, Eduardo.
Afiliación
  • Doneddu PE; Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Gallo C; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Gentile L; Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Cocito D; Unit of Neurology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • Falzone Y; Dipartimento Scienze Cliniche e Biologiche, Università di Torino, Turin, Italy.
  • Di Stefano V; Division of Neuroscience, Department of Neurology, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.
  • Inghilleri M; Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo, Italy.
  • Cosentino G; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
  • Matà S; IRCCS Neuromed, Pozzilli, Italy.
  • Mazzeo A; Department of Brain and Behavioral Sciences, IRCCS Mondino Foundation, University of Pavia, Pavia, Italy.
  • Filosto M; Neurology Unit, Dipartimento Neuromuscoloscheletrico e degli organi di Senso, Careggi University Hospital, Florence, Italy.
  • Peci E; Unit of Neurology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
  • Sorrenti B; NeMO-Brescia Clinical Center for Neuromuscular Diseases, ERN Euro-NMD Center ASST Spedali Civili, Brescia, Italy.
  • Brighina F; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
  • Moret F; Presidio Sanitario Major, Istituti Clinici Scientifici Maugeri, Turin, Italy.
  • Vegezzi E; Division of Neuroscience, Department of Neurology, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.
  • Sperti M; Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo, Italy.
  • Risi B; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
  • Nobile-Orazio E; IRCCS Neuromed, Pozzilli, Italy.
Eur J Neurol ; : e16444, 2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39236307
ABSTRACT
BACKGROUND AND

PURPOSE:

This study was undertaken to compare the sensitivity and specificity of the 2010 European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) diagnostic criteria for multifocal motor neuropathy (MMN) with those of the American Association of Electrodiagnostic Medicine (AAEM).

METHODS:

Sensitivity and specificity of the two sets of criteria were retrospectively evaluated in 53 patients with MMN and 280 controls with axonal peripheral neuropathy, inflammatory demyelinating polyneuropathy, or amyotrophic lateral sclerosis. Comparison of the utility of nerve conduction studies with different numbers of nerves examined was also assessed.

RESULTS:

The 2010 EFNS/PNS criteria had a sensitivity of 47% for definite MMN and 57% for probable/definite MMN, whereas the AAEM criteria had a sensitivity of 28% for definite MMN and 53% for probable/definite MMN. The sensitivity of the AAEM criteria was higher when utilizing area compared to amplitude reduction to define conduction block. Using supportive criteria, the sensitivity of the 2010 EFNS/PNS criteria for probable/definite MMN increased to 64%, and an additional 36% patients fulfilled the criteria (possible MMN). Specificity values for definite and probable/definite MMN were slightly higher with the AAEM criteria (100%) compared to the EFNS/PNS criteria (98.5% and 97%). Extended nerve conduction studies yielded slightly increased diagnostic sensitivity for both sets of criteria without significantly affecting specificity.

CONCLUSIONS:

In our patient populations, the 2010 EFNS/PNS criteria demonstrated higher sensitivity but slightly lower specificity compared to the AAEM criteria. Extended nerve conduction studies are advised to achieve slightly higher sensitivity while maintaining very high specificity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido