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The use of ectopic volar fibroblasts to modify skin identity.
Lee, Sam S; Sweren, Evan; Dare, Erika; Derr, Paige; Derr, Kristy; Wang, Chen Chia; Hardesty, Brooke; Willis, Aiden A; Chen, Junjie; Vuillier, Jonathan K; Du, Joseph; Wool, Julia; Ruci, Amanda; Wang, Vicky Y; Lee, Chaewon; Iyengar, Sampada; Asami, Soichiro; Daskam, Maria; Lee, Claudia; Lee, Jeremy C; Cho, Darren; Kim, Joshua; Martinez-Peña, Eddie Gibson; Lee, So Min; He, Xu; Wakeman, Michael; Sicilia, Iralde; Dobbs, Dalhart T; van Ee, Amy; Li, Ang; Xue, Yingchao; Williams, Kaitlin L; Kirby, Charles S; Kim, Dongwon; Kim, Sooah; Xu, Lillian; Wang, Ruizhi; Ferrer, Marc; Chen, Yun; Kang, Jin U; Kalhor, Reza; Kang, Sewon; Garza, Luis A.
Afiliación
  • Lee SS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Sweren E; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Dare E; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Derr P; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Derr K; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Wang CC; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Hardesty B; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Willis AA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Chen J; Department of Mechanical Engineering, Johns Hopkins University, MD 21210, USA.
  • Vuillier JK; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Du J; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Wool J; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Ruci A; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Wang VY; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Lee C; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Iyengar S; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Asami S; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Daskam M; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Lee C; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Lee JC; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Cho D; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Kim J; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Martinez-Peña EG; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Lee SM; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • He X; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Wakeman M; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Sicilia I; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Dobbs DT; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • van Ee A; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Li A; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Xue Y; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Williams KL; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Kirby CS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Kim D; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Kim S; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Xu L; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Wang R; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Ferrer M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Chen Y; Department of Mechanical Engineering, Johns Hopkins University, MD 21210, USA.
  • Kang JU; Department of Electrical and Computer Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Kalhor R; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Kang S; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Garza LA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Science ; 385(6713): eadi1650, 2024 Sep 06.
Article en En | MEDLINE | ID: mdl-39236183
ABSTRACT
Skin identity is controlled by intrinsic features of the epidermis and dermis and their interactions. Modifying skin identity has clinical potential, such as the conversion of residual limb and stump (nonvolar) skin of amputees to pressure-responsive palmoplantar (volar) skin to enhance prosthesis use and minimize skin breakdown. Greater keratin 9 (KRT9) expression, higher epidermal thickness, keratinocyte cytoplasmic size, collagen length, and elastin are markers of volar skin and likely contribute to volar skin resiliency. Given fibroblasts' capacity to modify keratinocyte differentiation, we hypothesized that volar fibroblasts influence these features. Bioprinted skin constructs confirmed the capacity of volar fibroblasts to induce volar keratinocyte features. A clinical trial of healthy volunteers demonstrated that injecting volar fibroblasts into nonvolar skin increased volar features that lasted up to 5 months, highlighting a potential cellular therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Queratinocitos / Dermis / Refuerzo Biomédico / Epidermis / Fibroblastos / Bioimpresión Límite: Adult / Female / Humans / Male Idioma: En Revista: Science Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Queratinocitos / Dermis / Refuerzo Biomédico / Epidermis / Fibroblastos / Bioimpresión Límite: Adult / Female / Humans / Male Idioma: En Revista: Science Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos