Your browser doesn't support javascript.
loading
The effect of excessive trabeculation on cardiac rotation-A multimodal imaging study.
Grebur, Kinga; Mester, Balázs; Horváth, Márton; Farkas-Süto, Kristóf; Gregor, Zsófia; Kiss, Anna Réka; Tóth, Attila; Kovács, Attila; Fábián, Alexandra; Lakatos, Bálint Károly; Fekete, Bálint András; Csonka, Katalin; Bödör, Csaba; Merkely, Béla; Vágó, Hajnalka; Szucs, Andrea.
Afiliación
  • Grebur K; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Mester B; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Horváth M; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Farkas-Süto K; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Gregor Z; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Kiss AR; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Tóth A; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Kovács A; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Fábián A; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Lakatos BK; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Fekete BA; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Csonka K; Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
  • Bödör C; Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
  • Merkely B; Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
  • Vágó H; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
  • Szucs A; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
PLoS One ; 19(9): e0308035, 2024.
Article en En | MEDLINE | ID: mdl-39236040
ABSTRACT

BACKGROUND:

Cardiac rotational parameters in primary symptomatic left ventricular noncompaction (LVNC) with preserved left ventricular ejection fraction (LVEF) are not well understood. We aimed to analyze cardiac rotation measured with cardiac magnetic resonance feature-tracking (CMR-FT) and speckle-tracking echocardiography (Echo-ST) in LVNC morphology subjects with preserved LVEF and different genotypes and healthy controls.

METHODS:

Our retrospective study included 54 LVNC subjects with preserved LVEF and 54 control individuals. We evaluated functional and rotational parameters with CMR in the total study population and with echocardiography in 39 LVNC and 40 C individuals. All LVNC subjects were genotyped with a 174-gene next-generation sequencing panel and grouped into the subgroups benign (B), variant of uncertain significance (VUS), and pathogenic (P).

RESULTS:

In comparison with controls, LVNC subjects had reduced apical rotational degree (p = 0.004) and one-third had negative apical rotation. While the degree of apical rotation was comparable between the three genetic subgroups, they differed significantly in the direction of apical rotation (p<0.001). In contrast to control and B groups, all four studied cardiac rotational patterns were identified in the P and VUS subgroups, namely normal rotation, positive and negative rigid body rotation, and reverse rotation. When the CMR-FT and Echo-ST methods were compared, the direction and pattern of cardiac rotation had moderate to good association (p<0.001) whereas the rotational degrees showed no reasonable correlation or agreement.

CONCLUSION:

While measuring cardiac rotation using both CMR-FT and Echo-ST methods, subclinical mechanical differences were identified in subjects with LVNC phenotype and preserved LVEF, especially in cases with genetic involvement.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ecocardiografía / Imagen Multimodal Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ecocardiografía / Imagen Multimodal Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos