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Repurposing methuosis-inducing anticancer drugs for anthelmintic therapy.
Rajasekharan, Satish Kumar; Ravichandran, Vinothkannan; Boya, Bharath Reddy; Jayachandran, Anirudh; Lee, Jintae.
Afiliación
  • Rajasekharan SK; Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Chengalpattu District, Kattankulathur, Tamil Nadu, India.
  • Ravichandran V; Centre for Drug Discovery and Development (CD3), Amity Institute of Biotechnology, Amity University Maharashtra, Bhatan, Panvel, Mumbai, Maharashtra, India.
  • Boya BR; School of Chemical Engineering, Yeungnum University, Gyeongsan, Republic of Korea.
  • Jayachandran A; Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Chengalpattu District, Kattankulathur, Tamil Nadu, India.
  • Lee J; School of Chemical Engineering, Yeungnum University, Gyeongsan, Republic of Korea.
PLoS Pathog ; 20(9): e1012475, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39235992
ABSTRACT
Drug-resistant parasitic nematodes pose a grave threat to plants, animals, and humans. An innovative paradigm for treating parasitic nematodes is emphasized in this opinion. This approach relies on repurposing methuosis (a death characterized by accumulation of large vacuoles) inducing anticancer drugs as anthelmintics. We review drugs/chemicals that have shown to kill nematodes or cancerous cells by inducing multiple vacuoles that eventually coalesce and rupture. This perspective additionally offers a succinct summary on Structure-Activity Relationship (SAR) of methuosis-inducing small molecules. This strategy holds promise for the development of broad-spectrum anthelmintics, shedding light on shared molecular mechanisms between cancer and nematodes in response to these inducers, thereby potentially transforming both therapeutic domains.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reposicionamiento de Medicamentos / Antihelmínticos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: PLoS Pathog Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reposicionamiento de Medicamentos / Antihelmínticos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: PLoS Pathog Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos