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Patterns of metabolic response in patients receiving commercial CAR T-cells for relapsing/refractory aggressive B cells lymphoma.
Vercellino, Laetitia; Betterki, Siham; Blanc, Estelle; de Kerviler, Eric; Cristinelli, Caterina; Merlet, Pascal; Thieblemont, Catherine; Meignin, Véronique; Di Blasi, Roberta.
Afiliación
  • Vercellino L; Nuclear Medicine Department, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris.
  • Betterki S; Nuclear Medicine Department, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris.
  • Blanc E; Nuclear Medicine Department, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris.
  • de Kerviler E; Radiology Department, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris.
  • Cristinelli C; Onco-hematology Department, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris.
  • Merlet P; Nuclear Medicine Department, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris.
  • Thieblemont C; Onco-hematology Department, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris.
  • Meignin V; Pathology Department, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris.
  • Di Blasi R; Onco-hematology Department, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris.
Br J Radiol ; 2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39235920
ABSTRACT
CAR T-cells is an innovative treatment for relapsed/refractory aggressive B cell lymphomas, initially proposed as third line therapy and beyond, now allowed as soon as second-line treatment for patients with early relapse after first-line treatment. FDG PET/CT remains the modality of choice to evaluate response to this therapeutic strategy, to detect or confirm treatment failure and allow for salvage therapy if needed. Correct classification of patients regarding response is thus of the utmost importance. In many cases, metabolic response follows classical known patterns, and Deauville score and Lugano criteria yield accurate characterization of patient status. However, given its specific mode of action, it can result in delayed response or atypical patterns of response. We report here a few examples of response from our experience to illustrate the existence of tricky cases. These atypical cases require multidisciplinary management, with clinical, biological, imaging and pathological work-up.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Br J Radiol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Br J Radiol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido