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RNA N6-methyladenosine modification in arthritis: New insights into pathogenesis.
Chen, Haowei; Xuan, Anran; Shi, Xiaorui; Fan, Tianxiang; Xue, Song; Ruan, Jianzhao; Wang, Xiaoshuai; Tang, Su'an; Qi, Weizhong; Sun, Haitao; Liu, Canzhao; He, Shuai; Ding, Changhai; Zhu, Zhaohua.
Afiliación
  • Chen H; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Xuan A; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Shi X; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Fan T; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Xue S; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China.
  • Ruan J; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Wang X; Department of Rheumatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Tang S; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Qi W; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Sun H; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Liu C; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • He S; Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Ding C; Department of Cardiovascular Medicine, Translational Medicine Research Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Zhu Z; Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Mod Rheumatol ; 2024 Aug 23.
Article en En | MEDLINE | ID: mdl-39235765
ABSTRACT
The commonest type of eukaryotic RNA modification, N6-methyladenosine (m6A), has drawn increased scrutiny in the context of pathological functioning as well as relevance in determination of RNA stability, splicing, transportation, localization, and translation efficiency. The m6A modification plays an important role in several types of arthritis, especially osteoarthritis and rheumatoid arthritis. Recent studies have reported that m6A modification regulates arthritis pathology in cells, such as chondrocytes and synoviocytes via immune responses and inflammatory responses through functional proteins classified as writers, erasers, and readers. The aim of this review was to highlight recent advances relevant to m6A modification in the context of arthritis pathogenesis and detail underlying molecular mechanisms, regulatory functions, clinical applications, and future perspectives of m6A in arthritis with the aim of providing a foundation for future research directions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mod Rheumatol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mod Rheumatol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido