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Robust Chiral Metal-Organic Framework Coatings for Self-Activating and Sustainable Biofouling Mitigation.
Yu, Zhiqun; Li, Xiangyu; Wang, Zhengxing; Fan, Yongqiang; Zhao, Wenjie; Li, Dianzhong; Xu, Dake; Gu, Tingyue; Wang, Fuhui.
Afiliación
  • Yu Z; Corrosion and Protection Center, Northeastern University, Shenyang, 110819, P. R. China.
  • Li X; Corrosion and Protection Center, Northeastern University, Shenyang, 110819, P. R. China.
  • Wang Z; College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.
  • Fan Y; College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.
  • Zhao W; Key Laboratory of Advanced Marine Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, P. R. China.
  • Li D; Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, P. R. China.
  • Xu D; Corrosion and Protection Center, Northeastern University, Shenyang, 110819, P. R. China.
  • Gu T; Department of Chemical and Biomolecular Engineering, Edison Biotechnology Institute, Ohio University, Athens, OH, 45701, USA.
  • Wang F; Corrosion and Protection Center, Northeastern University, Shenyang, 110819, P. R. China.
Adv Mater ; : e2407409, 2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39235391
ABSTRACT
Surface coatings are designed to mitigate pervasive biofouling herald, a new era of surface protection in complex biological environments. However, existing strategies are plagued by persistent and recurrent biofilm attachment, despite the use of bactericidal agents. Herein, a chiral metal-organic framework (MOF)-based coating with conformal microstructures to enable a new anti-biofouling mode that involves spontaneous biofilm disassembly followed by bacterial eradication is developed. A facile and universal metal-polyphenol network (MPN) is designed to robustly anchor the MOF nanoarmor of biocidal Cu2+ ions and anti-biofilm d-amino acid ligands to a variety of substrates across different material categories and surface topologies. Incorporating a diverse array of chiral amino acids endows the resultant coatings with widespread signals for biofilm dispersal, facilitating copper-catalyzed chemodynamic reactions and inherent mechano-bactericidal activities. This synergistic mechanism yields unprecedented anti-biofouling efficacy elucidated by RNA-sequencing transcriptomics analysis, enhancing broad-spectrum antibacterial activities, preventing biofilm formation, and destroying mature biofilms. Additionally, the chelation-directed amorphous/crystalline coatings can activate photoluminescent properties to inhibit the settlement of microalgae biofilms. This study provides a distinctive perspective on chirality-enhanced antimicrobial behaviors and pioneers a rational pathway toward developing next-generation anti-biofouling coatings for diverse applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania