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Occupational exposure to 50 ppm isoflurane impairs sperm parameters in mice.
Zanin, Marina; Varela Junior, Antonio Sergio; Acosta, Izani Bonel; da Silva, Edenara Anastacio; Dode, Maria Eduarda Bicca; Gehrcke, Martielo Ivan; Braz, Mariana Gobbo; Corcini, Carine Dahl.
Afiliación
  • Zanin M; Program in Physiological Sciences, Institute of Biological Sciences, Federal University of Rio Grande, Rio Grande, RS, Brazil.
  • Varela Junior AS; RAC - Center for teaching and research in animal reproduction, Faculty of Veterinary Medicine, Federal University of Pelotas, Pelotas, RS, Brazil.
  • Acosta IB; RAC - Center for teaching and research in animal reproduction, Faculty of Veterinary Medicine, Federal University of Pelotas, Pelotas, RS, Brazil.
  • da Silva EA; RAC - Center for teaching and research in animal reproduction, Faculty of Veterinary Medicine, Federal University of Pelotas, Pelotas, RS, Brazil.
  • Dode MEB; RAC - Center for teaching and research in animal reproduction, Faculty of Veterinary Medicine, Federal University of Pelotas, Pelotas, RS, Brazil.
  • Gehrcke MI; Faculty of Veterinary Medicine, Federal University of Pelotas, Pelotas, RS, Brazil.
  • Braz MG; UNIPEX - GENOTOX laboratory (Division of Anesthesiology) - Botucatu Medical School, São Paulo State University - UNESP, Botucatu, SP, Brazil.
  • Corcini CD; Program in Physiological Sciences, Institute of Biological Sciences, Federal University of Rio Grande, Rio Grande, RS, Brazil.
J Occup Environ Med ; 2024 Sep 04.
Article en En | MEDLINE | ID: mdl-39234938
ABSTRACT

OBJECTIVE:

To assess the effect of occupational exposure to isoflurane on the sperm quality of mice, and to investigate whether cessation of exposure can restore seminal quality.

METHODS:

Mice were exposed to 50 ppm of isoflurane for 5 hours per day over a 30-day period. Following this exposure, they were euthanized at predetermined post-exposure intervals, and their sperm samples were analyzed for kinetics and viability parameters.

RESULTS:

Occupational exposure to isoflurane can adversely affect sperm at 50 ppm, a concentration deemed safe by international occupational health conventions in some countries. These effects are marked by oxidative stress, mitochondrial dysfunction, and genomic damage, alongside alterations in sperm kinetics and acrosomal integrity. Furthermore, cessation of exposure doesn't guarantee restoration of cellular quality.

CONCLUSIONS:

Isoflurane at 50 ppm, previously deemed safe by some countries, impairs sperm kinetics and viability, potentially directing the spermatogenic process towards infertility and apoptosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Occup Environ Med Asunto de la revista: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Occup Environ Med Asunto de la revista: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos