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Estrogen deficiency-mediated osteoimmunity in postmenopausal osteoporosis.
Yao, Yao; Cai, Xiaoyu; Chen, Yue; Zhang, Meng; Zheng, Caihong.
Afiliación
  • Yao Y; Department of Pharmacy, Women's Hospital School of Medicine Zhejiang University, Hangzhou, China.
  • Cai X; Department of Pharmacy, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
  • Chen Y; Department of Pharmacy, Women's Hospital School of Medicine Zhejiang University, Hangzhou, China.
  • Zhang M; Department of Pharmacy, Women's Hospital School of Medicine Zhejiang University, Hangzhou, China.
  • Zheng C; Department of Pharmacy, Women's Hospital School of Medicine Zhejiang University, Hangzhou, China.
Med Res Rev ; 2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39234932
ABSTRACT
Postmenopausal osteoporosis (PMO) is a common disease associated with aging, and estrogen deficiency is considered to be the main cause of PMO. Recently, however, osteoimmunology has been revealed to be closely related to PMO. On the one hand, estrogen deficiency directly affects the activity of bone cells (osteoblasts, osteoclasts, osteocytes). On the other hand, estrogen deficiency-mediated osteoimmunity also plays a crucial role in bone loss in PMO. In this review, we systematically describe the progress of the mechanisms of bone loss in PMO, estrogen deficiency-mediated osteoimmunity, the differences between PMO patients and postmenopausal populations without osteoporosis, and estrogen deficiency-mediated immune cells (T cells, B cells, macrophages, neutrophils, dendritic cells, and mast cells) activity. The comprehensive summary of this paper provides a clear knowledge context for future research on the mechanism of PMO bone loss.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Med Res Rev Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Med Res Rev Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos