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Bioassay-Guided Fractionation of Acetone and Methanol Extracts of Quercus infectoria Galls with Antimalarial Properties.
Hamidon, Nurul Hammizah; Dona, Anjana Chamilka Thuduhenage; Zin, Nik Nor Imam Nik Mat; Nordin, Nurul Izza; Sulaiman, Shaida Fariza; Abu-Bakar, Nurhidanatasha.
Afiliación
  • Hamidon NH; School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
  • Dona ACT; SIRIM BERHAD, Institute of Biotechnology Research Centre, Block 19, No. 1, Persiaran Dato Menteri, Section 2, 40700 Shah Alam, Selangor, Malaysia.
  • Zin NNINM; School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
  • Nordin NI; School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
  • Sulaiman SF; SIRIM BERHAD, Institute of Biotechnology Research Centre, Block 19, No. 1, Persiaran Dato Menteri, Section 2, 40700 Shah Alam, Selangor, Malaysia.
  • Abu-Bakar N; SIRIM BERHAD, Institute of Biotechnology Research Centre, Block 19, No. 1, Persiaran Dato Menteri, Section 2, 40700 Shah Alam, Selangor, Malaysia.
Trop Life Sci Res ; 35(2): 167-185, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39234468
ABSTRACT
The antimalarial properties of crude extracts from Quercus infectoria galls were investigated through bioassay-guided fractionation. Acetone (QIA) and methanol (QIM) crude extracts have been reported to have promising antimalarial activity against Plasmodium falciparum (3D7 strain). These extracts were subjected to fractionation using automated preparative high-performance liquid chromatography (prep-HPLC) to identify the most active fractions. Nine fractions were isolated from each extract, of which the fractions QIA11 and QIM16 showed antimalarial activity, with IC50 values of 17.65 ± 1.82 µg/mL and 24.21 ± 1.88 µg/mL, respectively. In comparison, the standard antimalarial drug artemisinin has an IC50 value of 0.004 ± 0.001 µg/mL). Through high-resolution liquid chromatography coupled with mass spectrometry (HR-LCMS) analysis of the fractions, four known compounds were successfully identified gallic acid, ellagic acid, 1,3,6-tris-o-(3,4,5-trihydroxybenzoyl)-beta-d-glucose and 1-O,6-O-digalloyl-beta-D-glucose.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Trop Life Sci Res Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Malasia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Trop Life Sci Res Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Malasia