Eosinophil extracellular traps in respiratory ailment: Pathogenic mechanisms and clinical translation.
World J Otorhinolaryngol Head Neck Surg
; 10(3): 213-224, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39233861
ABSTRACT
Background:
Eosinophilic extracellular traps (EETs) are reticular complexes comprising deoxyribonucleic-Acid (DNA) fibers and granule proteins.Aims:
EETs play a crucial role in antimicrobial host responses and are pathogenic when overproduced or under degraded. EETs created by eosinophils appear to enable vital immune responses against extra-cellular pathogens, nevertheless, trap overproduction is evident in pathology. Materials &Methods:
As considerably research is performed, new data affirmed that EETs can alter the outcome of respiratory ailment.Results:
We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic, unresolved inflammation.Discussion:
Whether EETs can be used as a prospective brand-new target for the diagnosis, treatment and prognosis of respiratory ailments is a scientific theme worth studying.Conclusion:
We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic, unresolved inflammation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
World J Otorhinolaryngol Head Neck Surg
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos