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Construction of Liposome-Based Extracellular Artificial Organelles on Individual Living Cells.
Yang, Seoin; Youn, Wongu; Rheem, Hyeong Bin; Han, Sang Yeong; Kim, Nayoung; Han, Sol; Schattling, Philipp; Städler, Brigitte; Choi, Insung S.
Afiliación
  • Yang S; Department of Chemistry, KAIST, 34141, Daejeon, South Korea.
  • Youn W; Department of Chemistry, KAIST, 34141, Daejeon, South Korea.
  • Rheem HB; Department of Chemistry, KAIST, 34141, Daejeon, South Korea.
  • Han SY; Department of Chemistry, KAIST, 34141, Daejeon, South Korea.
  • Kim N; Department of Chemistry, KAIST, 34141, Daejeon, South Korea.
  • Han S; Department of Chemistry, KAIST, 34141, Daejeon, South Korea.
  • Schattling P; Interdisciplinary Nanoscience Center, iNANO), Aarhus University, Gustav Wieds Vej 14, 8000, Aarhus, Denmark.
  • Städler B; Interdisciplinary Nanoscience Center, iNANO), Aarhus University, Gustav Wieds Vej 14, 8000, Aarhus, Denmark.
  • Choi IS; Department of Chemistry, KAIST, 34141, Daejeon, South Korea.
Angew Chem Int Ed Engl ; : e202415823, 2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39233597
ABSTRACT
Integration of living cells with extrinsic functional entities gives rise to bioaugmented nanobiohybrids, which hold tremendous potential across diverse fields such as cell therapy, biocatalysis, and cell robotics. This study presents a biocompatible method for incorporating multilayered functional liposomes onto the cell surface, creating extracellular artificial organelles or exorganelles. The introduction of various extrinsic functionalities to cells is achieved without comprising their viabilities. The integration of extrinsic enzymatic reactions is exemplified through the cascade reaction involving glucose oxidase and horseradish peroxidase. Furthermore, our protocol offers the design flexibility to customize liposome compositions, thereby providing effective cell modification. The versatility of the liposome-based exorganelle approach establishes an advanced chemical tool, empowering cells with novel functionalities that surpass or are complementary to their innate capabilities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Alemania