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Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5-HT2A and D2 receptor interaction pathways.
Islam, Muhammad Torequl; Chowdhury, Raihan; Bhuia, Md Shimul; Chakrabarty, Brototi; Kundu, Neloy; Akbor, Md Showkot; Sheikh, Salehin; Chowdhury, Rokibul Islam; Ansari, Siddique Akber; Ansari, Irfan Aamer; Islam, Md Amirul.
Afiliación
  • Islam MT; Pharmacy Discipline, Khulna University, Khulna, Bangladesh.
  • Chowdhury R; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
  • Bhuia MS; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Bangladesh, Gopalganj, Bangladesh.
  • Chakrabarty B; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
  • Kundu N; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Bangladesh, Gopalganj, Bangladesh.
  • Akbor MS; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
  • Sheikh S; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Bangladesh, Gopalganj, Bangladesh.
  • Chowdhury RI; Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
  • Ansari SA; Pharmacy Discipline, Khulna University, Khulna, Bangladesh.
  • Ansari IA; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
  • Islam MA; Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
Drug Dev Res ; 85(6): e22259, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39233388
ABSTRACT
Schizophrenia affects identification and disturbs our thinking and motivational capacity. Long-term use of daidzin (DZN) is evident to enhance attention and memory in experimental animals. This study aimed to investigate the effect of DZN on Swiss mice. To check animals' attention, identification, thinking, and motivational ability, we performed behavioral studies using marble burying, dust removal, and trained swimming protocols. For this, a total of 36 male Swiss albino mice were randomly divided into six groups, consisting of 6 animals in each group, as follows control (vehicle), DZN-1.25, DZN-2.5, DZN-5 mg/kg, olanzapine (OLN)-2, and a combination of DZN-1.25 with OLN-2. Additionally, in silico studies are also performed to understand the possible molecular mechanisms behind this neurological effect. Findings suggest that DZN dose-dependently and significantly (p < .05) increased marble burying and removed dust while reducing the time to reach the target point. DZN-1.25 was found to enhance OLN's effect significantly (p < .05), possibly via agonizing its activity in animals. In silico findings suggest that DZN has strong binding affinities of -10.1 and -10.4 kcal/mol against human serotonin 2 A (5-HT2A) and dopamine 2 (D2) receptors, respectively. Additionally, DZN exhibits favorable pharmacokinetic and toxicity properties. We suppose that DZN may exert its attention- and memory-enhancing abilities by interacting with 5-HT2A and D2 receptors. It may exert a synergistic antischizophrenia-like effect with the standard drug, OLN. Further studies are required to discover the exact molecular mechanism for this neurological function in animals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antipsicóticos / Receptores de Dopamina D2 / Receptor de Serotonina 5-HT2A / Olanzapina / Memoria Límite: Animals Idioma: En Revista: Drug Dev Res Año: 2024 Tipo del documento: Article País de afiliación: Bangladesh Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antipsicóticos / Receptores de Dopamina D2 / Receptor de Serotonina 5-HT2A / Olanzapina / Memoria Límite: Animals Idioma: En Revista: Drug Dev Res Año: 2024 Tipo del documento: Article País de afiliación: Bangladesh Pais de publicación: Estados Unidos