Your browser doesn't support javascript.
loading
Recurrent and De Novo Focal Segmental Glomerulosclerosis After Kidney Transplantation: Comparison of Clinical Features and Transplant Outcomes.
Kim, Do Kyun; Huh, Hyuk; Kim, Yunmi; Kim, Taehee; Kim, Yeong Hoon; Choi, Byung Hyun; Lee, Hyun Jeong; Kang, Mi Seon; Kim, Seo Rin; Lee, Dong Won; Lee, Soo Bong; Kim, Il Young.
Afiliación
  • Kim DK; Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
  • Huh H; Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea.
  • Kim Y; Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea.
  • Kim T; Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea.
  • Kim YH; Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea.
  • Choi BH; Department of Surgery, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Lee HJ; Department of Pathology, Pusan National University School of Medicine, Yangsan, Republic of Korea.
  • Kang MS; Department of Pathology, Inje University Busan Paik Hospital, Busan, Republic of Korea.
  • Kim SR; Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
  • Lee DW; Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
  • Lee SB; Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
  • Kim IY; Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. Electronic address: iykim@pusan.ac.kr.
Transplant Proc ; 56(8): 1752-1756, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39232925
ABSTRACT

BACKGROUND:

Focal segmental glomerulosclerosis (FSGS) is a notable subtype of glomerulonephritis in kidney transplantation, often resulting in graft failure. Yet, research comparing transplant outcomes between de novo and recurrent FSGS is scarce. This study aims to compare clinical features and transplant outcomes between these two categories.

METHODS:

This retrospective study enrolled 773 kidney transplant recipients from two centers between January 2008 and October 2021. Patients diagnosed with FSGS through graft kidney biopsy were included. They were categorized into two groups based on the time of FSGS occurrence and results of native kidney biopsy the recurrent FSGS group and the de novo FSGS group.

RESULTS:

Of 773 kidney transplant patients, 24 had primary FSGS-causing end-stage renal disease. During a median 65-month follow-up, 5 of these patients developed recurrent FSGS (incidence 26.3%). Among 749 patients with other kidney diseases causing end-stage renal disease, 9 had de novo FSGS (incidence 1.2%). In the recurrent FSGS group, 2 out of 5 patients experienced graft failure, with no deaths or acute rejections. Similarly, in the de novo FSGS group, 3 out of 9 patients experienced graft failure, with no deaths or acute rejections. Kaplan-Meier analysis showed slower graft loss in de novo FSGS, resulting in a higher graft survival rate compared to recurrent FSGS (probability of graft survival, 60% vs 33.3%, P = .036).

CONCLUSIONS:

Graft loss progresses more slowly in de novo FSGS compared to recurrent FSGS, resulting in a higher long-term graft survival rate in de novo FSGS than in recurrent FSGS.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recurrencia / Glomeruloesclerosis Focal y Segmentaria / Trasplante de Riñón / Supervivencia de Injerto / Fallo Renal Crónico Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recurrencia / Glomeruloesclerosis Focal y Segmentaria / Trasplante de Riñón / Supervivencia de Injerto / Fallo Renal Crónico Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos