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Outcomes of Intraoperative Frozen Section Examination of Surgical Resection Margins of the Penis in Penile Cancer.
Pang, Karl H; Yunis, Mohammad; Haider, Aiman; Freeman, Alex; Hadway, Paul; Nigam, Raj; Rees, Rowland; Muneer, Asif; Alnajjar, Hussain M.
Afiliación
  • Pang KH; Institute of Andrology, University College London Hospitals NHS Foundation Trust, London, UK; Division of Surgery and Interventional Science, University College London, London, UK.
  • Yunis M; King's College London Medical School, London, UK.
  • Haider A; Department of Histopathology, University College London Hospitals NHS Foundation Trust, London, UK.
  • Freeman A; Department of Histopathology, University College London Hospitals NHS Foundation Trust, London, UK.
  • Hadway P; Institute of Andrology, University College London Hospitals NHS Foundation Trust, London, UK; Department of Urology, Royal Berkshire NHS Foundation Trust, Reading, UK.
  • Nigam R; Institute of Andrology, University College London Hospitals NHS Foundation Trust, London, UK; Department of Urology, Royal Surrey NHS Foundation Trust, Guildford, UK.
  • Rees R; Institute of Andrology, University College London Hospitals NHS Foundation Trust, London, UK; Department of Urology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Muneer A; Institute of Andrology, University College London Hospitals NHS Foundation Trust, London, UK; Division of Surgery and Interventional Science, University College London, London, UK; Department of Surgical Biotechnology, University College London, London, UK; NIHR Biomedical Research Centre, Universit
  • Alnajjar HM; Institute of Andrology, University College London Hospitals NHS Foundation Trust, London, UK; Division of Surgery and Interventional Science, University College London, London, UK. Electronic address: Hussain.alnajjar@nhs.net.
Clin Genitourin Cancer ; 22(5): 102189, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39232874
ABSTRACT

INTRODUCTION:

Frozen section examination (FSE) of the tumor resection margins is important during penile-preserving surgery (PPS) in penile cancer. The margin status will impact on how much penile or urethral tissue is excised. We aim to evaluate the outcomes of intraoperative FSE of resection margins in PPS. PATIENTS AND

METHODS:

A retrospective analysis of patients with penile squamous cell carcinoma (SCC) who underwent a FSE of resection margins between 2010 and 2022 was conducted. FSEs were compared with the final histopathological analysis and the Diagnostic Testing Accuracy (DTA) sensitivity, specificity, positive (PPV) and negative predictive values (NPV) were calculated.

RESULTS:

Overall, 137 FSE were performed. The median (IQR) age was 65 (53-75) years. 118 (86.1%) patients had negative FSE margins, 16 (11.7%) had positive FSE margins and 3 (2.2%) had equivocal (atypical cells) results. The sensitivity, specificity, PPV, NPV and diagnostic accuracy of penile FSE were 66.7%, 100%, 100%, 93.2% and 94% respectively. 18 patients underwent further resection in the same episode due to a positive or equivocal FSE and 12 (66.7%) achieved negative margins. Limitations include the retrospective nature of the study and lack of control arm to compare with.

CONCLUSIONS:

Intraoperative FSE performed at our center for the assessment of penile SCC margins is 66.7% sensitive and 100% specific. FSE should be considered in PPS, as it's an essential and a reliable diagnostic tool in minimizing over-treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Pene / Carcinoma de Células Escamosas / Márgenes de Escisión / Secciones por Congelación Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: Clin Genitourin Cancer Asunto de la revista: NEOPLASIAS / UROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Pene / Carcinoma de Células Escamosas / Márgenes de Escisión / Secciones por Congelación Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: Clin Genitourin Cancer Asunto de la revista: NEOPLASIAS / UROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos