Your browser doesn't support javascript.
loading
Amygdala connectivity is associated with withdrawn/depressed behavior in a large sample of children from the Adolescent Brain Cognitive Development (ABCD) Study®.
Thomas, Elina; Juliano, Anthony; Owens, Max; Cupertino, Renata B; Mackey, Scott; Hermosillo, Robert; Miranda-Dominguez, Oscar; Conan, Greg; Ahmed, Moosa; Fair, Damien A; Graham, Alice M; Goode, Nicholas J; Kandjoze, Uapingena P; Potter, Alexi; Garavan, Hugh; Albaugh, Matthew D.
Afiliación
  • Thomas E; Department of Psychiatry, University of Vermont Medical Center, 111 Colchester Avenue Burlington, VT, 05401, USA; Department of Psychology, Earlham College, 801 W National Rd, Richmond, IN 47374, USA. Electronic address: thomael@earlham.edu.
  • Juliano A; Department of Psychiatry, University of Vermont Medical Center, 111 Colchester Avenue Burlington, VT, 05401, USA.
  • Owens M; Department of Psychiatry, University of Vermont Medical Center, 111 Colchester Avenue Burlington, VT, 05401, USA.
  • Cupertino RB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
  • Mackey S; Department of Psychiatry, University of Vermont Medical Center, 111 Colchester Avenue Burlington, VT, 05401, USA.
  • Hermosillo R; Department of Pediatrics, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA; Masonic Institute for the Developing Brain, University of Minnesota, 2025 East River Parkway, Minneapolis, MN 55313, USA.
  • Miranda-Dominguez O; Department of Pediatrics, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA; Masonic Institute for the Developing Brain, University of Minnesota, 2025 East River Parkway, Minneapolis, MN 55313, USA.
  • Conan G; Department of Pediatrics, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA; Masonic Institute for the Developing Brain, University of Minnesota, 2025 East River Parkway, Minneapolis, MN 55313, USA.
  • Ahmed M; Department of Pediatrics, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA; Masonic Institute for the Developing Brain, University of Minnesota, 2025 East River Parkway, Minneapolis, MN 55313, USA.
  • Fair DA; Department of Pediatrics, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA; Masonic Institute for the Developing Brain, University of Minnesota, 2025 East River Parkway, Minneapolis, MN 55313, USA.
  • Graham AM; Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA.
  • Goode NJ; Department of Psychology, Earlham College, 801 W National Rd, Richmond, IN 47374, USA.
  • Kandjoze UP; Department of Psychology, Earlham College, 801 W National Rd, Richmond, IN 47374, USA.
  • Potter A; Department of Psychiatry, University of Vermont Medical Center, 111 Colchester Avenue Burlington, VT, 05401, USA.
  • Garavan H; Department of Psychiatry, University of Vermont Medical Center, 111 Colchester Avenue Burlington, VT, 05401, USA.
  • Albaugh MD; Department of Psychiatry, University of Vermont Medical Center, 111 Colchester Avenue Burlington, VT, 05401, USA.
Psychiatry Res Neuroimaging ; 344: 111877, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39232266
ABSTRACT
Many psychopathologies tied to internalizing symptomatology emerge during adolescence, therefore identifying neural markers of internalizing behavior in childhood may allow for early intervention. We utilized data from the Adolescent Brain and Cognitive Development (ABCD) Study® to evaluate associations between cortico-amygdalar functional connectivity, polygenic risk for depression (PRSD), traumatic events experienced, internalizing behavior, and internalizing subscales withdrawn/depressed behavior, somatic complaints, and anxious/depressed behaviors. Data from 6371 children (ages 9-11) were used to analyze amygdala resting-state fMRI connectivity to Gordon parcellation based whole-brain regions of interest (ROIs). Internalizing behaviors were measured using the parent-reported Child Behavior Checklist. Linear mixed-effects models were used to identify patterns of cortico-amygdalar connectivity associated with internalizing behaviors. Results indicated left amygdala connections to auditory, frontoparietal network (FPN), and dorsal attention network (DAN) ROIs were significantly associated with withdrawn/depressed symptomatology. Connections relevant for withdrawn/depressed behavior were linked to social behaviors. Specifically, amygdala connections to DAN were associated with social anxiety, social impairment, and social problems. Additionally, an amygdala connection to the FPN ROI and the auditory network ROI was associated with social anxiety and social problems, respectively. Therefore, it may be important to account for social behaviors when looking for brain correlates of depression.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Depresión / Amígdala del Cerebelo Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Depresión / Amígdala del Cerebelo Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos