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Identification of concurrent infection with Jaagsiekte sheep retrovirus and maedi-visna virus in China.
Duan, Xujie; Shi, Xiaona; Zhang, Pei; Du, Xiaoyue; Chen, Sixu; Zhang, Liang; Li, Huiping; Zhang, Yufei; Wang, Jinling; Ding, Yulin; Liu, Shuying.
Afiliación
  • Duan X; College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
  • Shi X; Inner Mongolia Key Laboratory of Basic Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
  • Zhang P; Key Laboratory of Clinical Diagnosis and Treatment Technology for Animal Disease, Ministry of Agriculture, Hohhot 010018, China.
  • Du X; College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
  • Chen S; Inner Mongolia Key Laboratory of Basic Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
  • Zhang L; Key Laboratory of Clinical Diagnosis and Treatment Technology for Animal Disease, Ministry of Agriculture, Hohhot 010018, China.
  • Li H; College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
  • Zhang Y; Inner Mongolia Key Laboratory of Basic Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
  • Wang J; Key Laboratory of Clinical Diagnosis and Treatment Technology for Animal Disease, Ministry of Agriculture, Hohhot 010018, China.
  • Ding Y; College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
  • Liu S; Inner Mongolia Key Laboratory of Basic Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
J Vet Sci ; 2024 Aug 08.
Article en En | MEDLINE | ID: mdl-39231786
ABSTRACT
IMPORTANCE Ovine pulmonary adenomatosis (OPA) and maedi-visna disease (MVD) are chronic and progressive infectious diseases in sheep caused by Jaagsiekte sheep retrovirus (JSRV) and maedi-visna virus (MVV), respectively.

OBJECTIVE:

To investigate the pathological changes and conduct viral gene analysis of OPA and MVD co-occurrence in Inner Mongolia, China.

METHODS:

Using gross pathology, histopathology, immunohistochemistry, ultrastructural pathology, PCR, and sequence analysis, we investigated the concurrent infection of JSRV and MVV in 319 Dorper rams slaughtered in a private slaughterhouse in Inner Mongolia, in 2022.

RESULTS:

Of the 319 rams included, 3 showed concurrent JSRV and MVV infection. Gross lung pathology showed diffuse enlargement, consolidation, and greyish-white miliary nodules on the lung surface; the trachea was filled with a white foamy fluid; hilar and mediastinal lymph nodes were significantly enlarged. Histopathology results revealed typical OPA and MVD lesions in the lung tissue. Immunohistochemical results were positive for JSRV envelope protein (Env) in the tumor cells and MVV CA in alveolar macrophages. Transmission electron microscopy showed several virions and autophagosomes in the lung tissue, severely damaged mitochondria, and the induced mitophagy. Nucleotide sequences obtained for JSRV env and MVV gag showed the highest homology with the Inner Mongolian strains of JSRV env (JQ837489) and MVV gag (MW248464). CONCLUSIONS AND RELEVANCE Our study confirmed that OPA and MVD co-occurrence and identified the pathological changes in Inner Mongolia, China, thereby providing references for the identification of concurrent JSRV and MVV infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Vet Sci Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación:
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Vet Sci Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: