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Non-HDL-C, Symptomatic Intracranial Arterial Stenosis, and Recurrent Vascular Risk in Minor Stroke.
Fan, Haimei; Liu, Tingting; Zhang, Kaili; Wang, Yongle; Wang, Rong; Yang, Fei; Chen, Feifei; Zhang, Yanli; Guo, Huaai; Li, Xinyi; Wu, Xuemei; Niu, Xiaoyuan.
Afiliación
  • Fan H; Department of Neurology, Sixth Hospital of Shanxi Medical University (General Hospital of Tisco).
  • Liu T; Department of Neurology, First Hospital of Shanxi Medical University.
  • Zhang K; Department of Neurology, First Hospital of Shanxi Medical University.
  • Wang Y; Department of Neurology, Shanxi Bethune Hospital (Third Hospital of Shanxi Medical University).
  • Wang R; Department of Neurology, First Hospital of Shanxi Medical University.
  • Yang F; Department of Neurology, Sixth Hospital of Shanxi Medical University (General Hospital of Tisco).
  • Chen F; Department of Neurology, Sixth Hospital of Shanxi Medical University (General Hospital of Tisco).
  • Zhang Y; Department of Neurology, Sixth Hospital of Shanxi Medical University (General Hospital of Tisco).
  • Guo H; Department of Neurology, Sixth Hospital of Shanxi Medical University (General Hospital of Tisco).
  • Li X; Department of Neurology, Sixth Hospital of Shanxi Medical University (General Hospital of Tisco).
  • Wu X; Department of Neurology, Shanxi Bethune Hospital (Third Hospital of Shanxi Medical University).
  • Niu X; Department of Neurology, Sixth Hospital of Shanxi Medical University (General Hospital of Tisco).
J Atheroscler Thromb ; 2024 Sep 04.
Article en En | MEDLINE | ID: mdl-39231649
ABSTRACT

AIM:

We aimed to assess the association between non-high-density lipoprotein cholesterol (non-HDL-C) and symptomatic intracranial artery stenosis (sICAS), as well as the impact of non-HDL-C on recurrent vascular events in patients with mild ischemic stroke ( NIHSS score ≤ 5).

METHODS:

This prospective study was based on data from patients presenting within 72 hours of stroke occurrence. We included patients admitted to 8 Chinese hospitals between September 2019 and November 2021. The associations of non-HDL-C with sICAS and recurrent vascular risk were assessed using multivariate regression models and a restricted cubic spline analysis.

RESULTS:

Among the 2,544 patients analyzed at 12 months, 652 (25.6%) were diagnosed with sICAS. Elevated non-HDL-C was linked to a higher incidence of sICAS, and the adjusted odd ratios for quintile variables and continuous variables were 1.36 ([95% CI, 1.01-1.81]) and 1.14 ([95% CI, 1.04-1.24). In comparison to those in the first quintile, the adjusted hazard ratio of the fifth quintile of non-HDL-C was 1.19 ([95% CI 0.78-1.80]) for recurrent ischemic stroke and was 0.39 ([95% CI, 0.17-0.91]) for intracranialhemorrhage.

CONCLUSIONS:

The non-HDL-C level may be a useful predictor of sICAS. Higher non-HDL-C levels may be associated with a lower risk of intracranial hemorrhage in mild, noncardiogenic stroke, but not a higher risk of recurrent ischemic stroke.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Atheroscler Thromb Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Atheroscler Thromb Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Japón