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Clinical significance of coefficient of variation in continuous glucose monitoring for glycemic management in children and adolescents with type 1 diabetes.
Urakami, Tatsuhiko; Terada, Hiroki; Tanabe, Satomi; Mine, Yusuke; Aoki, Masako; Aoki, Ryoji; Suzuki, Junichi; Morioka, Ichiro.
Afiliación
  • Urakami T; Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
  • Terada H; Urakami Pediatric Endocrinology and Diabetes Clinic, Tokyo, Japan.
  • Tanabe S; Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
  • Mine Y; Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
  • Aoki M; Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
  • Aoki R; Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
  • Suzuki J; Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
  • Morioka I; Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
J Diabetes Investig ; 15(11): 1669-1674, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39230367
ABSTRACT
AIMS/

INTRODUCTION:

Coefficient of variation (CV) is an indicator for glucose variability in continuous glucose monitoring (CGM), and the target threshold of %CV in type 1 diabetes is proposed to be ≤36%. This study aimed to evaluate the clinical significance of CV in children and adolescents with type 1 diabetes. MATERIALS AND

METHODS:

Participants included 66 children with type 1 diabetes. A total of 48 participants were treated with multiple daily injections of insulin, and 18 with continues subcutaneous insulin infusion, using intermittently scanned CGM. The frequencies of the CGM metrics and glycosylated hemoglobin values were examined, and the significance of a threshold %CV of 36% was evaluated.

RESULTS:

The mean frequencies in time in range (TIR), time below range, %CV and the mean glycosylated hemoglobin value were 59.3 ± 16.1, 4.0 ± 3.5, 39.3 ± 6.2 and 7.3 ± 0.8%, respectively. The frequencies of participants who achieved a TIR >70% and a %CV of ≤36% were 24.1 and 27.3%, respectively. A total of 18 participants with a %CV of ≤36% had significantly higher TIR, lower time below range and lower glycosylated hemoglobin than the 48 with a %CV of >36% (72.6 ± 12.6 vs 52.4 ± 13.6, 2.4 ± 1.9 vs 4.6 ± 3.6, 6.9 ± 0.8 vs 7.4 ± 0.7%, respectively).

CONCLUSIONS:

Children and adolescents with type 1 diabetes using intermittently scanned CGM had difficulties in achieving the recommended targets of TIR and CV. However, the target %CV of ≤36% seems to be an appropriate indicator for assessing glycemic control and risk of hypoglycemia in pediatric patients with type 1 diabetes with any treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Hemoglobina Glucada / Automonitorización de la Glucosa Sanguínea / Diabetes Mellitus Tipo 1 / Control Glucémico / Hipoglucemiantes / Insulina Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Diabetes Investig Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Hemoglobina Glucada / Automonitorización de la Glucosa Sanguínea / Diabetes Mellitus Tipo 1 / Control Glucémico / Hipoglucemiantes / Insulina Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Diabetes Investig Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón