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Improvement effect of compound Ento-PB on oxazolone-induced ulcerative colitis in rats.
Fan, Zhi; Chen, Jinhu; Wei, Jia; Yang, ZhiBin; Xiao, Huai; Liu, Heng.
Afiliación
  • Fan Z; Dali University - Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical - Dali - China.
  • Chen J; Dali University - Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical - Dali - China.
  • Wei J; Dali University - National-Local Joint Engineering Research Center of Entomoceutics - Dali - China.
  • Yang Z; Dali University - Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical - Dali - China.
  • Xiao H; Dali University - Engineering Research Center for Development and Comprehensive Utilization of Entomoceutics - Dali - China.
  • Liu H; Dali University - Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical - Dali - China.
Acta Cir Bras ; 39: e395524, 2024.
Article en En | MEDLINE | ID: mdl-39230095
ABSTRACT

PURPOSE:

To investigate the impact of the Chinese medicine compound Ento-PB on oxazolone (OXZ)-induced ulcerative colitis (UC) in rats.

METHODS:

UC rats induced by OXZ were treated with Ento-PB. The damage to the colon was assessed using several measures, including the disease activity index (DAI), colon length, colon weight/length ratio, colonic mucosal damage index, and histological score. The levels of interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-13 (IL-13), epidermal growth factor (EGF), inducible nitric oxide synthase, and total nitric oxide synthase (tNOS) in rat serum, as well as the levels of tumor necrosis factor-α (TNF-α) and myeloperoxidase (MPO) in rat colon tissue, were determined using enzyme-linked immunosorbent assay and conventional kits.

RESULTS:

After being treated with Ento-PB, the DAI score and macroscopic lesion score of OXZ-induced UC rats were significantly reduced. Ento-PB prevented the shortening of rat colons, reduced the ratio of colon weight to length, and improved colon tissue lesions. Meanwhile, Ento-PB could significantly inhibit the activities of proinflammatory cytokines TNF-α, IL-13, and MPO, as well as tNOS and iNOS, while upregulating the expression of anti-inflammatory cytokines IL-4 and IL-10. Moreover, a significant increase in the expression level of EGF was observed in UC rats treated with Ento-PB, indicating that Ento-PB could enhance the repair of damaged intestinal epithelial tissue.

CONCLUSIONS:

Ento-PB demonstrates significant anti-UC activities in OXZ-induced UC rats by regulating the expression levels of inflammatory factors and promoting the repair of colon tissue. This study provides scientific evidence to support the further development of Ento-PB.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Oxazolona / Colon / Peroxidasa Límite: Animals Idioma: En Revista: Acta Cir Bras Año: 2024 Tipo del documento: Article Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Oxazolona / Colon / Peroxidasa Límite: Animals Idioma: En Revista: Acta Cir Bras Año: 2024 Tipo del documento: Article Pais de publicación: Brasil