Your browser doesn't support javascript.
loading
The association between acute kidney injury and dysglycaemia in critically ill patients with and without diabetes mellitus: a retrospective single-center study.
Zhang, Chong; Ning, Meng; Liang, Weiru; Su, Wei; Chen, Yi; Guo, Tingting; Hu, Kun; Peng, Wenjin; Liu, Yingwu.
Afiliación
  • Zhang C; The Third Central Clinical College of Tianjin Medical University, Tianjin, China.
  • Ning M; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China.
  • Liang W; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China.
  • Su W; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China.
  • Chen Y; Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin, China.
  • Guo T; The Third Central Clinical College of Tianjin Medical University, Tianjin, China.
  • Hu K; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China.
  • Peng W; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China.
  • Liu Y; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China.
Ren Fail ; 46(2): 2397555, 2024 Dec.
Article en En | MEDLINE | ID: mdl-39230066
ABSTRACT

BACKGROUND:

Critically ill patients in the intensive care unit (ICU) often experience dysglycaemia. However, studies investigating the link between acute kidney injury (AKI) and dysglycaemia, especially in those with and without diabetes mellitus (DM), are limited.

METHODS:

We used the Medical Information Mart for Intensive Care IV database to investigate the association between AKI within 7 days of admission and subsequent dysglycaemia. The primary outcome was the occurrence of dysglycaemia (both hypoglycemia and hyperglycemia) after 7 days of ICU admission. Logistic regression analyzed the relationship between AKI and dysglycaemia, while a Cox proportional hazards model estimated the long-term mortality risk linked to the AKI combined with dysglycaemia.

RESULTS:

A cohort of 20,008 critically ill patients were included. The AKI group demonstrated a higher prevalence of dysglycaemia, compared to the non-AKI group. AKI patients had an increased risk of dysglycaemia (adjusted odds ratio [aOR] 1.53, 95% confidence interval [CI] 1.41-1.65), hypoglycemia (aOR 1.56, 95% CI 1.41-1.73), and hyperglycemia (aOR 1.53, 95% CI 1.41-1.66). In subgroup analysis, compared to DM patients, AKI showed higher risk of dysglycaemia in non-DM patients (aOR 1.93 vs. 1.33, Pint<0.01). Additionally, the AKI with dysglycaemia group exhibited a higher risk of long-term mortality compared to the non-AKI without dysglycaemia group. Dysglycaemia also mediated the relationship between AKI and long-term mortality.

CONCLUSION:

AKI was associated with a higher risk of dysglycaemia, especially in non-DM patients, and the combination of AKI and dysglycaemia was linked to higher long-term mortality. Further research is needed to develop optimal glycemic control strategies for AKI patients.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Lesión Renal Aguda / Hiperglucemia / Hipoglucemia / Unidades de Cuidados Intensivos Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Lesión Renal Aguda / Hiperglucemia / Hipoglucemia / Unidades de Cuidados Intensivos Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido