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Do Existing MRI Definitions of Knee Osteoarthritis Identify Knees That Will Develop Clinically Significant Disease Over Up To 11 Years of Follow-Up?
Chang, Alison H; Roemer, Frank W; Guermazi, Ali; Almagor, Orit; Lee, Jungwha Julia; Chmiel, Joan S; Muhammad, Lutfiyya N; Song, Jing; Sharma, Leena.
Afiliación
  • Chang AH; Department of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Roemer FW; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany.
  • Guermazi A; Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA, USA.
  • Almagor O; Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA, USA.
  • Lee JJ; Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Chmiel JS; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Muhammad LN; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Song J; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Sharma L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Arthritis Rheumatol ; 2024 Sep 04.
Article en En | MEDLINE | ID: mdl-39229747
ABSTRACT

OBJECTIVES:

In individuals without radiographic knee osteoarthritis (KOA), we investigated whether MRI-defined KOA at baseline was associated with incident radiographic and symptomatic disease during up to 11 years of follow-up.

METHODS:

Osteoarthritis Initiative participants without tibiofemoral radiographic KOA at baseline were assessed for MRI-based tibiofemoral cartilage damage, osteophyte presence, bone marrow lesions, and meniscal damage/extrusion. We defined MRI KOA using alternative, reported definitions (Def A and Def B). Kellgren-Lawrence (KL) grade, joint space narrowing (JSN), and frequent knee symptoms (Sx) were assessed at baseline, 1-, 2-, 3-, 4-, 6-, 8-, and 10/11-year follow-up visits. Incident tibiofemoral radiographic KOA (outcome) was defined as (1) KL ≥ 2, (2) KL ≥ 2 and JSN, or (3) KL ≥ 2 and Sx. Adjusted Cox proportional hazards regression models examined associations of baseline MRI-defined KOA (Def A and Def B) with incident outcomes during up to 11 years of follow-up.

RESULTS:

Among 1621 participants [mean age=58.8 (SD=9.0) years, mean BMI=27.2 (4.5) kg/m2, 59.5% women], 17% had MRI-defined KOA by Def A and 24% by Def B. Baseline MRI-defined KOA was associated with incident KL ≥ 2 [odds ratio=2.94 (95% CI=2.34-3.68) for Def A and 2.44 (95% CI=1.97-3.03) for Def B]. However, a substantial proportion of individuals with baseline MRI-defined KOA did not develop incident KL ≥ 2 during follow-up (59% for Def A and 64% for Def B). Findings were similar for the other two outcomes.

CONCLUSIONS:

Current MRI definitions of KOA do not adequately identify knees that will develop radiographic and symptomatic disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arthritis Rheumatol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arthritis Rheumatol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos