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Extracellular vesicles containing fullerene derivatives prepared by an exchange reaction for photodynamic therapy.
Kono, Nanami; Kawasaki, Riku; Oshige, Ayano; Nishimura, Kotaro; Yamana, Keita; Yimiti, Dilimulati; Miyaki, Shigeru; Adachi, Nobuo; Takabayashi, Naoki; Nagasaki, Takeshi; Ikeda, Atsushi.
Afiliación
  • Kono N; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi Hiroshima, 739-8527, Japan. riku0528@hiroshima-u.ac.jp.
  • Kawasaki R; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi Hiroshima, 739-8527, Japan. riku0528@hiroshima-u.ac.jp.
  • Oshige A; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi Hiroshima, 739-8527, Japan. riku0528@hiroshima-u.ac.jp.
  • Nishimura K; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi Hiroshima, 739-8527, Japan. riku0528@hiroshima-u.ac.jp.
  • Yamana K; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi Hiroshima, 739-8527, Japan. riku0528@hiroshima-u.ac.jp.
  • Yimiti D; Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima, 734-8551, Japan.
  • Miyaki S; Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima, 734-8551, Japan.
  • Adachi N; Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima, 734-8551, Japan.
  • Takabayashi N; Department of Applied Chemistry and Bioengineering, Graduate School of Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka, 558-8585, Japan.
  • Nagasaki T; Department of Applied Chemistry and Bioengineering, Graduate School of Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka, 558-8585, Japan.
  • Ikeda A; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi Hiroshima, 739-8527, Japan. riku0528@hiroshima-u.ac.jp.
J Mater Chem B ; 12(38): 9760-9766, 2024 Oct 02.
Article en En | MEDLINE | ID: mdl-39229703
ABSTRACT
Extracellular vesicles (EVs) have excellent biocompatibility and long retention times in the circulation and have consequently been expected to be useful as drug-delivery systems. However, their applications have been limited because of the inability to introduce hydrophobic compounds to EVs without the use of harmful organic solvents. Herein, we developed an organic-solvent-free drug-loading technique based on the host exchange reaction. We demonstrated that the exchange reaction enabled quantitative loading of EVs with highly concentrated (0.1 mM) hydrophobic fullerene derivatives. Fullerene derivative-loaded EVs (EVs/C60) could eliminate cancer cell lines more efficiently than fullerene derivative-loaded liposomes (Lip/C60). Moreover, the photodynamic activity of EVs/C60 was fivefold higher than that of the clinically available photosensitizer photofrin. EVs/C60 could efficiently suppress tumor growth in tumor-xenograft model mice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Fármacos Fotosensibilizantes / Fulerenos / Vesículas Extracelulares Límite: Animals / Female / Humans Idioma: En Revista: J Mater Chem B Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Fármacos Fotosensibilizantes / Fulerenos / Vesículas Extracelulares Límite: Animals / Female / Humans Idioma: En Revista: J Mater Chem B Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido