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Peritoneal lavage cytology in patients with curative resection for stage II and III colorectal cancer: A multi-institutional prospective study.
Kobayashi, Hirotoshi; Kotake, Kenjiro; Maeda, Kotaro; Suto, Takeshi; Kawasaki, Masayasu; Ueno, Hideki; Komori, Koji; Ozawa, Heita; Koda, Keiji; Ohue, Masayuki; Funahashi, Kimihiko; Takemasa, Ichiro; Ishida, Hideyuki; Kazama, Shinsuke; Shimada, Yoshifumi; Morohashi, Hajime; Kinugasa, Yusuke; Kanemitsu, Yukihide; Ochiai, Hiroki; Ishihara, Soichiro; Itabashi, Michio; Sugihara, Kenichi; Ajioka, Yoichi.
Afiliación
  • Kobayashi H; Department of Surgery Tokyo Metropolitan Hiroo Hospital Tokyo Japan.
  • Kotake K; Department of Surgery Teikyo University Hospital Mizonokuchi Kanagawa Japan.
  • Maeda K; Department of Surgery Sano City Hospital Tochigi Japan.
  • Suto T; International Medical Center Fujita Health University Hospital Toyoake Japan.
  • Kawasaki M; Department of Gastroenterological Surgery Yamagata Prefectural Central Hospital Yamagata Japan.
  • Ueno H; Department of Surgery Bell Land General Hospital Sakai Japan.
  • Komori K; Department of Surgery National Defense Medical College Tokorozawa Japan.
  • Ozawa H; Department of Gastroenterological Surgery Aichi Cancer Center Hospital Aichi Japan.
  • Koda K; Department of Surgery Tochigi Cancer Center Utsunomiya Japan.
  • Ohue M; Teikyo University Chiba Medical Center Ichihara City Japan.
  • Funahashi K; Department of Gastroenterological Surgery Osaka International Cancer Institute Osaka Japan.
  • Takemasa I; Department of General and Gastroenterological Surgery Toho University Omori Medical Center Tokyo Japan.
  • Ishida H; Department of Surgery, Surgical Oncology and Science Sapporo Medical University Sapporo Japan.
  • Kazama S; Department of Digestive Tract and General Surgery, Saitama Medical Center Saitama Medical University Kawagoe Japan.
  • Shimada Y; Department of Gastroenterological Surgery Saitama Cancer Center.
  • Morohashi H; Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata Japan.
  • Kinugasa Y; Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine Aomori Japan.
  • Kanemitsu Y; Department of Gastrointestinal Surgery Tokyo Medical and Dental University Tokyo Japan.
  • Ochiai H; Department of Colorectal Surgery National Cancer Center Hospital Tokyo Japan.
  • Ishihara S; Department of Surgery Teikyo University School of Medicine Tokyo Japan.
  • Itabashi M; Department of Surgical Oncology The University of Tokyo Hospital Tokyo Japan.
  • Sugihara K; Department of Surgery, Institute of Gastroenterology Tokyo Women's Medical University Tokyo Japan.
  • Ajioka Y; Tokyo Medical and Dental University Tokyo Japan.
Ann Gastroenterol Surg ; 8(5): 807-816, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39229555
ABSTRACT

Aim:

To clarify the usefulness of intraoperative lavage cytology in patients undergoing curative resection for pStage II-III colorectal cancer in a prospective multicenter study.

Methods:

Patients preoperatively diagnosed with stage II-III colorectal cancer between 2013 and 2017 from 20 hospitals were enrolled. Lavage cytology was performed twice during the surgery. The primary endpoint was the effect of lavage cytology on the 5-year relapse-free survival (RFS) in patients with pStage II-III colorectal cancer. The secondary endpoint was the effect of lavage cytology on the 5-year overall survival (OS) and peritoneal recurrence.

Results:

A total of 1378 patients were eligible for analysis. The number of patients with pStage II-III colorectal cancer was 670 and 708, respectively. Fifty-four patients (3.9%) had positive cytological results. In pStage II patients, the 5-year RFS rates with positive and negative cytology were 61.1% and 81.6%, respectively (p = 0.023). The 5-year OS rates were 67.1% and 91.7%, respectively (p = 0.0083). However, there was no difference in RFS or OS between pStage III patients with positive and negative cytology results. The peritoneal recurrence rates were 11.8% and 1.5% in pStage II patients with positive and negative cytology results, respectively (p = 0.032). These rates were 10.5% and 2.5% in patients with stage III disease, respectively (p = 0.022).

Conclusion:

Stage II colorectal cancer patients with negative cytology had better outcomes than those with positive cytology. Peritoneal lavage cytology is useful for predicting peritoneal recurrence after curative resection of stage II-III colorectal cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Gastroenterol Surg Año: 2024 Tipo del documento: Article Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Gastroenterol Surg Año: 2024 Tipo del documento: Article Pais de publicación: Japón