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Factors associated with cognitive impairment before intracerebral haemorrhage: community-based neuropathological study.
Xiang, Yawen; Rodrigues, Mark A; Lerpiniere, Christine; Moullaali, Tom J; Loan, James J M; Wilkinson, Tim; Humphreys, Catherine A; Smith, Colin; Al-Shahi Salman, Rustam; Samarasekera, Neshika.
Afiliación
  • Xiang Y; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Rodrigues MA; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Lerpiniere C; Department of Neuroradiology, NHS Lothian, Edinburgh EH16 4SA, UK.
  • Moullaali TJ; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Loan JJM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Wilkinson T; Faculty of Medicine, The George Institute for Global Health, University of New South Wales, Sydney, NSW 2042, Australia.
  • Humphreys CA; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Smith C; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Al-Shahi Salman R; Usher Institute, University of Edinburgh, Edinburgh EH8 9AG, UK.
  • Samarasekera N; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Brain Commun ; 6(5): fcae275, 2024.
Article en En | MEDLINE | ID: mdl-39229490
ABSTRACT
Little is known about whether clinical, radiological or neuropathological features are associated with cognitive impairment before intracerebral haemorrhage. We conducted a community-based cohort study of 125 adults with intracerebral haemorrhage (lobar n = 71, non-lobar n = 54) with consent to brain autopsy. We compared small vessel disease biomarkers on diagnostic CT head and neuropathological findings including neurofibrillary tangles and amyloid plaques in adults without cognitive impairment versus cognitive impairment without dementia versus dementia before intracerebral haemorrhage, stratified by lobar and non-lobar intracerebral haemorrhage. In non-lobar intracerebral haemorrhage, severe cortical atrophy was less common in those without cognitive impairment (8/36, 22%) and cognitive impairment without dementia (0/9, 0%) versus dementia (5/9, 56%); P = 0.008. Irrespective of intracerebral haemorrhage location, adults without cognitive impairment had milder neurofibrillary tangle pathology measured by median Braak stage (lobar intracerebral haemorrhage no cognitive impairment 2 [interquartile range, 2-3] versus cognitive impairment without dementia 4 [2-6] versus dementia 5.5 [4-6]; P = 0.004; non-lobar intracerebral haemorrhage no cognitive impairment 2 [1-2] versus cognitive impairment without dementia 2 [1-2] versus dementia 5 [3-6]; P < 0.001). Irrespective of intracerebral haemorrhage location, adults without cognitive impairment had milder amyloid plaque pathology measured by median Thal stage (lobar intracerebral haemorrhage no cognitive impairment 2 [1-2] versus cognitive impairment without dementia 2 [2-3] versus dementia 2.5 [2-3.5]; P = 0.033; non-lobar intracerebral haemorrhage no cognitive impairment 1 [0-1] versus cognitive impairment without dementia 0 [0-2] versus dementia 3 [2-3]; P = 0.002). Our findings suggest that irrespective of intracerebral haemorrhage location, adults with cognitive impairment before an intracerebral haemorrhage have more Alzheimer's disease neuropathologic change.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Commun Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Commun Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido