Your browser doesn't support javascript.
loading
Novel perspectives on leptin in osteoarthritis: Focus on aging.
Liu, Zimo; Xie, Wenqing; Li, Hengzhen; Liu, Xu; Lu, Yao; Lu, Bangbao; Deng, Zhenhan; Li, Yusheng.
Afiliación
  • Liu Z; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
  • Xie W; Xiangya School of Medicine, Central South University, Changsha, Hunan 410083, China.
  • Li H; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
  • Liu X; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
  • Lu Y; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
  • Lu B; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
  • Deng Z; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
  • Li Y; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Genes Dis ; 11(6): 101159, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39229323
ABSTRACT
Osteoarthritis (OA) is a common chronic joint disease characterized by articular cartilage degeneration, subchondral sclerosis, synovitis, and osteophyte formation. OA is associated with disability and impaired quality of life, particularly among the elderly. Leptin, a 16-kD non-glycosylated protein encoded by the obese gene, is produced on a systemic and local basis in adipose tissue and the infrapatellar fat pad located in the knee. The metabolic mechanisms employed by leptin in OA development have been widely studied, with attention being paid to aging as a corroborative risk factor for OA. Hence, in this review, we have attempted to establish a potential link between leptin and OA, by focusing on aging-associated mechanisms and proposing leptin as a potential diagnostic and therapeutic target in aging-related mechanisms of OA that may provide fruitful guidance and emphasis for future research.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Genes Dis Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Genes Dis Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos