Your browser doesn't support javascript.
loading
Association Between Antibodies That Bind Epstein-Barr Virus (EBV) gp350 and gH/gL and Shedding of EBV in Saliva From Nasopharyngeal Carcinoma Multiplex Family Members in Taiwan.
Liu, Kai-Lin; Hsu, Wan-Lun; Bu, Wei; Yu, Kelly J; Wang, Cheng-Ping; Chien, Yin-Chu; Chen, Tseng-Cheng; Chen, Chien-Jen; Hildesheim, Allan; Middeldorp, Jaap M; Waterboer, Tim; Cohen, Jeffrey I; Coghill, Anna E; Liu, Zhiwei.
Afiliación
  • Liu KL; Department of Biology, Department of Healthcare Management & Policy, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Hsu WL; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
  • Bu W; Master Program of Big Data in Medical Healthcare Industry, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
  • Yu KJ; Data Science Center, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
  • Wang CP; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Chien YC; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
  • Chen TC; Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan.
  • Chen CJ; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Hildesheim A; Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University, College of Medicine, Taipei, Taiwan.
  • Middeldorp JM; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Waterboer T; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
  • Cohen JI; Agencia Costarriciense de Investigaciones Biologicas, San Jose, Costa Rica.
  • Coghill AE; Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
  • Liu Z; Division of Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Open Forum Infect Dis ; 11(9): ofae464, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39229285
ABSTRACT
Elevated levels of Epstein-Barr virus (EBV) gp350 and gH/gL antibodies have been associated with a lower risk of developing nasopharyngeal carcinoma (NPC), although the evidence remains inconclusive and unexplained. We conducted a longitudinal study within a high-risk Taiwanese cohort, analyzing total immunoglobulin against EBV-gp350 and -gH/gL in blood and EBV DNA shedding in saliva. Contrary to our hypothesis-that elevated levels of antibodies previously shown to be associated with a lower NPC risk should result in a decrease in EBV shedding in saliva-higher anti-gp350 antibodies at baseline were significantly associated with detectable EBV DNA in saliva at follow-up (odds ratio [OR], 1.99 [95% confidence interval {CI}, 1.03-3.97]; P = .04). Higher anti-EBV-gH/gL antibodies at baseline were not significantly associated with risk of detectable EBV DNA at follow-up (OR, 0.69 [95% CI, .35-1.32]; P = .26). These findings underscore the complexity of virus-host interactions and emphasize the need for further investigations into their role in EBV-associated diseases.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Forum Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos