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PBMC-engrafted humanized mice models for evaluating immune-related and anticancer drug delivery systems.
Kametani, Yoshie; Ito, Ryoji; Manabe, Yoshiyuki; Kulski, Jerzy K; Seki, Toshiro; Ishimoto, Hitoshi; Shiina, Takashi.
Afiliación
  • Kametani Y; Department of Molecular Life Science, Division of Basic Medical Science, Tokai University School of Medicine, Isehara, Japan.
  • Ito R; Institute of Advanced Biosciences, Tokai University, Hiratsuka, Japan.
  • Manabe Y; Central Institute for Experimental Medicine and Life Science (CIEM), Kawasaki, Japan.
  • Kulski JK; Department of Chemistry, Graduate School of Science, Osaka University, Osaka, Japan.
  • Seki T; Department of Molecular Life Science, Division of Basic Medical Science, Tokai University School of Medicine, Isehara, Japan.
  • Ishimoto H; Faculty of Health and Medical Sciences, School of Biomedical Science, The University of Western Australia, Crawley, WA, Australia.
  • Shiina T; Department of Internal Medicine, Division of Nephrology, Endocrinology, and Metabolism, Tokai University School of Medicine, Isehara, Japan.
Front Mol Biosci ; 11: 1447315, 2024.
Article en En | MEDLINE | ID: mdl-39228913
ABSTRACT
Immune-related drug delivery systems (DDSs) in humanized mouse models are at the forefront of cancer research and serve as bridges between preclinical studies and clinical applications. These systems offer unique platforms for exploring new therapies and understanding their interactions with human cells and the immune system. Here, we focus on a DDS and a peripheral blood mononuclear cell (PBMC)-engrafted humanized mouse model that we recently developed, and consider some of the key components, challenges, and applications to advance these systems towards better cancer treatment on the basis of a better understanding of the immune response. Our DDS is unique and has a dual function, an anticancer effect and a capacity to fine-tune the immune reaction. The PBL-NOG-hIL-4-Tg mouse system is superior to other available humanized mouse systems for the development of such multifunctional DDSs because it supports the rapid reconstruction of an individual donor's immunity and avoids the onset of graft-versus-host disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Mol Biosci Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Mol Biosci Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza