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Admission Blood Glucose Associated with In-Hospital Mortality in Critically III Non-Diabetic Patients with Heart Failure: A Retrospective Study.
Chen, Yu; Wang, YingZhi; Chen, Fang; Chen, CaiHua; Dong, XinJiang.
Afiliación
  • Chen Y; Department of Cardiac Surgery, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, 317000 Linhai, Zhejiang, China.
  • Wang Y; Department of Cardiac Surgery, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, 317000 Linhai, Zhejiang, China.
  • Chen F; Department of Cardiac Surgery, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, 317000 Linhai, Zhejiang, China.
  • Chen C; Department of Cardiac Surgery, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, 317000 Linhai, Zhejiang, China.
  • Dong X; Department of Cardiology, Shanxi Cardiovascular Hospital, 030024 Taiyuan, Shanxi, China.
Rev Cardiovasc Med ; 25(8): 275, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39228488
ABSTRACT

Background:

Heart failure (HF) is a primary public health issue associated with a high mortality rate. However, effective treatments still need to be developed. The optimal level of glycemic control in non-diabetic critically ill patients suffering from HF is uncertain. Therefore, this study examined the relationship between initial glucose levels and in-hospital mortality in critically ill non-diabetic patients with HF.

Methods:

A total of 1159 critically ill patients with HF were selected from the Medical Information Mart for Intensive Care-III (MIMIC-III) data resource and included in this study. The association between initial glucose levels and hospital mortality in seriously ill non-diabetic patients with HF was analyzed using smooth curve fittings and multivariable Cox regression. Stratified analyses were performed for age, gender, hypertension, atrial fibrillation, CHD with no MI (coronary heart disease with no myocardial infarction), renal failure, chronic obstructive pulmonary disease (COPD), estimated glomerular filtration rate (eGFR), and blood glucose concentrations.

Results:

The hospital mortality was identified as 14.9%. A multivariate Cox regression model, along with smooth curve fitting data, showed that the initial blood glucose demonstrated a U-shape relationship with hospitalized deaths in non-diabetic critically ill patients with HF. The turning point on the left side of the inflection point was HR 0.69, 95% CI 0.47-1.02, p = 0.068, and on the right side, HR 1.24, 95% CI 1.07-1.43, p = 0.003. Significant interactions existed for blood glucose concentrations (7-11 mmol/L) (p-value for interaction 0.009). No other significant interactions were detected.

Conclusions:

This study demonstrated a U-shape correlation between initial blood glucose and hospital mortality in critically ill non-diabetic patients with HF. The optimal level of initial blood glucose for non-diabetic critically ill patients with HF was around 7 mmol/L.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Rev Cardiovasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Rev Cardiovasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur