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Association between Mir-499, Mir-27a, and Mir-146a polymorphisms and their susceptibility to recurrent spontaneous abortion; in silico analysis.
Bahari, Gholamreza; Taheri, Mohsen; Mokhtari, Mojgan; Moudi, Mahdiyeh; Majidpour, Mahdi; Ghadimi, Hossein Shahraki.
Afiliación
  • Bahari G; Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.
  • Taheri M; Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
  • Mokhtari M; Department of Obstetrics and Gynecology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Moudi M; Department of Medical Biotechnology, School of Medicine, Neyshabour University of Medical Sciences, Neyshabour, Razavi Khorasan Province, Iran.
  • Majidpour M; Clinical Immunology Research Center of Zahedan University of Medical Sciences, Zahedan, Iran.
  • Ghadimi HS; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Turk J Obstet Gynecol ; 21(3): 158-165, 2024 Sep 04.
Article en En | MEDLINE | ID: mdl-39228203
ABSTRACT

Objective:

Recurrent spontaneous abortion (RSA) is defined as two or more pregnancy losses before 24 gestational weeks, accounting for 1-3% of fertile couples. A vast majority of single-nucleotide polymorphisms (SNPs) in some microRNA (miRNA) genes can change the miRNA-mRNA interaction and are associated with the risk of RSA. This study was designed to better elucidate the association between miR-27a, miR-499, and miR-146a polymorphisms and RSA risk. Materials and

Methods:

SNP genotyping of miR-27a (rs895819), miR-499 (rs3746444), and miR-146a (rs2910164) was performed using polymerase chain reaction (PCR)-restriction fragment length polymorphism and tetra amplification-refractory mutation system PCR in 98 patients with RSA and 105 healthy subjects.

Results:

Our results showed that the miR-499 rs3746444 and miR-27a rs895819 polymorphisms were significantly associated with RSA risk, whereas no significant differences were observed between the rs2910164 polymorphism and RSA susceptibility.

Conclusion:

We proposed that the miR-499 rs3746444 and miR-27a rs895819 polymorphisms were correlated with RSA in our population, but the miR-146a rs2910164 variant was not associated with the risk of RSA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Turk J Obstet Gynecol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Turquía
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Turk J Obstet Gynecol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Turquía