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New-onset obstructive airway disease following COVID-19: a multicenter retrospective cohort study.
Chuang, Min-Hsiang; Hsu, Wei; Tsai, Ya-Wen; Hsu, Wan-Hsuan; Wu, Jheng-Yan; Liu, Ting-Hui; Huang, Po-Yu; Lai, Chih-Cheng.
Afiliación
  • Chuang MH; Division of Nephrology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
  • Hsu W; Division of Cardiology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
  • Tsai YW; Center for Integrative Medicine, Chi Mei Medical Center, Tainan, Taiwan.
  • Hsu WH; Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan.
  • Wu JY; Division of Cardiology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
  • Liu TH; Department of Nutrition, Chi Mei Medical Center, Tainan, Taiwan.
  • Huang PY; Department of Psychiatry, Chi Mei Medical Center, Tainan, Taiwan.
  • Lai CC; Division of Cardiology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
BMC Med ; 22(1): 360, 2024 Sep 04.
Article en En | MEDLINE | ID: mdl-39227934
ABSTRACT

BACKGROUND:

The study assessed the association between COVID-19 and new-onset obstructive airway diseases, including asthma, chronic obstructive pulmonary disease, and bronchiectasis among vaccinated individuals recovering from COVID-19 during the Omicron wave.

METHODS:

This multicenter retrospective cohort study comprised 549,606 individuals from the U.S. Collaborative Network of TriNetX database, from January 8, 2022, to January 17, 2024. The hazard of new-onset obstructive airway diseases between COVID-19 and no-COVID-19 groups were compared following propensity score matching using the Kaplan-Meier method and Cox proportional hazards model.

RESULTS:

After propensity score matching, each group contained 274,803 participants. Patients with COVID-19 exhibited a higher risk of developing new-onset asthma than that of individuals without COVID-19 (adjusted hazard ratio (aHR), 1.27; 95% CI, 1.22-1.33; p < 0.001). Stratified analyses by age, SARS-CoV-2 variant, vaccination status, and infection status consistently supported this association. Non-hospitalized individuals with COVID-19 demonstrated a higher risk of new-onset asthma (aHR, 1.27; 95% CI, 1.22-1.33; p < 0.001); however, no significant differences were observed in hospitalized and critically ill groups. The study also identified an increased risk of subsequent bronchiectasis following COVID-19 (aHR, 1.30; 95% CI, 1.13-1.50; p < 0.001). In contrast, there was no significant difference in the hazard of chronic obstructive pulmonary disease between the groups (aHR, 1.00; 95% CI, 0.95-1.06; p = 0.994).

CONCLUSION:

This study offers convincing evidence of the association between COVID-19 and the subsequent onset of asthma and bronchiectasis. It underscores the need for a multidisciplinary approach to post-COVID-19 care, with a particular focus on respiratory health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Enfermedad Pulmonar Obstructiva Crónica / COVID-19 Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: BMC Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Enfermedad Pulmonar Obstructiva Crónica / COVID-19 Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: BMC Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido