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Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study.
Wang, Shisong; Gao, Hui; Lin, Pengyao; Qian, Tianchen; Xu, Lei.
Afiliación
  • Wang S; Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, China.
  • Gao H; Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315010, China.
  • Lin P; Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315010, China.
  • Qian T; Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, China.
  • Xu L; Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315010, China.
BMC Gastroenterol ; 24(1): 299, 2024 Sep 04.
Article en En | MEDLINE | ID: mdl-39227758
ABSTRACT

BACKGROUND:

Increasing evidences suggest that nonalcoholic fatty liver disease (NAFLD) is associated with neuropsychiatric disorders. Nevertheless, whether there were causal associations between them remained vague. A causal association between neuropsychiatric disorders and NAFLD was investigated in this study.

METHODS:

We assessed the published genome-wide association study summary statistics for NAFLD, seven mental disorder-related diseases and six central nervous system dysfunction-related diseases. The causal relationships were first assessed using two-sample and multivariable Mendelian randomization (MR). Then, sensitivity analyses were performed, followed by a reverse MR analysis to determine whether reverse causality is possible. Finally, we performed replication analyses and combined the findings from the above studies.

RESULTS:

Our meta-analysis results showed NAFLD significantly increased the risk of anxiety disorders (OR = 1.016, 95% CI = 1.010-1.021, P value < 0.0001). In addition, major depressive disorder was the potential risk factor for NAFLD (OR = 1.233, 95% CI = 1.063-1.430, P value = 0.006). Multivariable MR analysis showed that the causal effect of major depressive disorder on NAFLD remained significant after considering body mass index, but the association disappeared after adjusting for the effect of waist circumference. Furthermore, other neuropsychiatric disorders and NAFLD were not found to be causally related.

CONCLUSIONS:

These results implied causal relationships of NAFLD with anxiety disorders and Major Depressive Disorder. This study highlighted the need to recognize and understand the connection between neuropsychiatric disorders and NAFLD to prevent the development of related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Enfermedad del Hígado Graso no Alcohólico / Trastornos Mentales Límite: Humans Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Enfermedad del Hígado Graso no Alcohólico / Trastornos Mentales Límite: Humans Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido