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A time-stratified, case-crossover study of heat exposure and perinatal mortality from 16 hospitals in sub-Saharan Africa.
Hanson, Claudia; de Bont, Jeroen; Annerstedt, Kristi Sidney; Alsina, Maria Del Rosario; Nobile, Federica; Roos, Nathalie; Waiswa, Peter; Pembe, Andrea; Dossou, Jean-Paul; Chipeta, Effie; Benova, Lenka; Kidanto, Hussein; Part, Cherie; Stafoggia, Massimo; Filippi, Veronique; Ljungman, Petter.
Afiliación
  • Hanson C; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. claudia.hanson@ki.se.
  • de Bont J; London School of Hygiene and Tropical Medicine, London, UK. claudia.hanson@ki.se.
  • Annerstedt KS; Centre of Excellence for Women and Child Health, Aga Khan University, Nairobi, Kenya. claudia.hanson@ki.se.
  • Alsina MDR; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Nobile F; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
  • Roos N; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
  • Waiswa P; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Pembe A; Department of Epidemiology, Lazio Region Health Service/ASL Roma 1, Rome, Italy.
  • Dossou JP; Clinical Epidemiology Division, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Chipeta E; Makerere University, Kampala, Uganda.
  • Benova L; Department of Obstetrics and Gynaecology, Muhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania.
  • Kidanto H; Centre de Recherche en Reproduction Humaine et en Démographie (CERRHUD), Cotonou, Benin.
  • Part C; Centre for Reproductive Health, Kamuzu University of Health Science, Blantyre, Malawi.
  • Stafoggia M; Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
  • Filippi V; Centre of Excellence for Women and Child Health, Aga Khan University, Nairobi, Kenya.
  • Ljungman P; London School of Hygiene and Tropical Medicine, London, UK.
Nat Med ; 2024 Sep 03.
Article en En | MEDLINE | ID: mdl-39227446
ABSTRACT
Growing evidence suggests that extreme heat events affect both pregnant women and their infants, but few studies are available from sub-Saharan Africa. Using data from 138,015 singleton births in 16 hospitals in Benin, Malawi, Tanzania and Uganda, we investigated the association between extreme heat and early perinatal deaths, including antepartum and intrapartum stillbirths, and deaths within 24 h after birth using a time-stratified case-crossover design. We observed an association between an increase from the 75th to the 99th percentile in mean temperature 1 week (lag 0-6 d) before childbirth and perinatal mortality (odds ratio (OR) = 1.34 (95% confidence interval (CI) 1.01-1.78)). The estimates for stillbirths were similarly positive, but CIs included unity OR = 1.29 (95% CI 0.95-1.77) for all stillbirths, OR = 1.18 (95% CI 0.71-1.95) for antepartum stillbirths and OR = 1.64 (95% CI 0.74-3.63) for intrapartum stillbirths. The cumulative exposure-response curve suggested that the steepest slopes for heat for intrapartum stillbirths and associations were stronger during the hottest seasons. We conclude that short-term heat exposure may increase mortality risks, particularly for intrapartum stillbirths, raising the importance of improved intrapartum care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos