Predicting the Progression of Mild Cognitive Impairment to Alzheimer's Dementia Using Recurrent Neural Networks With a Series of Neuropsychological Tests.

Park, Chaeyoon; Joo, Gihun; Roh, Minji; Shin, Seunghun; Yum, Sujin; Yeo, Na Young; Park, Sang Won; Jang, Jae-Won; Im, Hyeonseung

Park, Chaeyoon; Joo, Gihun; Roh, Minji; Shin, Seunghun; Yum, Sujin; Yeo, Na Young; Park, Sang Won; Jang, Jae-Won; Im, Hyeonseung.

Afiliación

Park C; Graduate School of Data Science, Kangwon National University, Chuncheon, Korea.
Joo G; Interdisciplinary Graduate Program in Medical Bigdata Convergence, Kangwon National University, Chuncheon, Korea.
Roh M; Interdisciplinary Graduate Program in Medical Bigdata Convergence, Kangwon National University, Chuncheon, Korea.
Shin S; Interdisciplinary Graduate Program in Medical Bigdata Convergence, Kangwon National University, Chuncheon, Korea.
Yum S; Interdisciplinary Graduate Program in Medical Bigdata Convergence, Kangwon National University, Chuncheon, Korea.
Yeo NY; Department of Neurology, Kangwon National University Hospital, Chuncheon, Korea.
Park SW; Interdisciplinary Graduate Program in Medical Bigdata Convergence, Kangwon National University, Chuncheon, Korea.
Jang JW; Department of Neurology, Kangwon National University Hospital, Chuncheon, Korea.
Im H; Department of Neurology, Kangwon National University Hospital, Chuncheon, Korea.

J Clin Neurol ; 20(5): 478-486, 2024 Sep.

Article en En | MEDLINE | ID: mdl-39227330

ABSTRACT

ABSTRACT

BACKGROUND AND

PURPOSE:

The prevalence of Alzheimer's dementia (AD) is increasing as populations age, causing immense suffering for patients, families, and communities. Unfortunately, no treatments for this neurodegenerative disease have been established. Predicting AD is therefore becoming more important, because early diagnosis is the best way to prevent its onset and delay its progression.

METHODS:

Mild cognitive impairment (MCI) is the stage between normal cognition and AD, with large variations in its progression. The disease can be effectively managed by accurately predicting the probability of MCI progressing to AD over several years. In this study we used the Alzheimer's Disease Neuroimaging Initiative dataset to predict the progression of MCI to AD over a 3-year period from baseline. We developed and compared various recurrent neural network (RNN) models to determine the predictive effectiveness of four neuropsychological (NP) tests and magnetic resonance imaging (MRI) data at baseline.

RESULTS:

The experimental results confirmed that the Preclinical Alzheimer's Cognitive Composite score was the most effective of the four NP tests, and that the prediction performance of the NP tests improved over time. Moreover, the gated recurrent unit model exhibited the best performance among the prediction models, with an average area under the receiver operating characteristic curve of 0.916.

CONCLUSIONS:

Timely prediction of progression from MCI to AD can be achieved using a series of NP test results and an RNN, both with and without using the baseline MRI data.

Palabras clave

Alzheimer's disease; dementia; mild cognitive impairment; neural network models; neuropsychological tests

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Neurol Año: 2024 Tipo del documento: Article Pais de publicación: