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Donor-derived infections-Insights from Singapore, Japan, and Thailand.
Tan, Sophie Seine Xuan; Phoompoung, Pakpoom; Okamoto, Koh; Chayakulkeeree, Methee; Koh, Xiu Xian; Tan, Chee-Kiat; Kong, Sally Nyuk Min; Tan, Thuan Tong; Chung, Shimin Jasmine; Tan, Ban Hock.
Afiliación
  • Tan SSX; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
  • Phoompoung P; Duke-NUS Medical School, Singapore, Singapore.
  • Okamoto K; Department of Medicine, Division of Infectious Disease and Tropical Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
  • Chayakulkeeree M; Department of Infectious Diseases, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Japan.
  • Koh XX; Department of Medicine, Division of Infectious Disease and Tropical Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
  • Tan CK; National Organ Transplant Unit, Ministry of Health, Singapore, Singapore.
  • Kong SNM; Duke-NUS Medical School, Singapore, Singapore.
  • Tan TT; National Organ Transplant Unit, Ministry of Health, Singapore, Singapore.
  • Chung SJ; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore.
  • Tan BH; National Organ Transplant Unit, Ministry of Health, Singapore, Singapore.
Transpl Infect Dis ; : e14370, 2024 Sep 03.
Article en En | MEDLINE | ID: mdl-39226139
ABSTRACT

BACKGROUND:

Solid organ transplantation (SOT) has expanded significantly in Asia over past few decades. Donor-derived infections (DDIs) remain a significant concern as they may adversely impact transplant outcomes. We aim to review the existing regulatory frameworks, screening protocols, and management practices for DDIs in Asia.

METHODS:

We reached out to transplant infectious diseases experts in Asia to provide standardized data on annual SOT numbers, incidence of DDIs, regulatory frameworks, donor and recipient screening protocols, and DDI surveillance measures. We present the data from Singapore, Japan, and Thailand.

RESULTS:

Donor screening for HIV, hepatitis B, hepatitis C, and syphilis is mandatory in all countries. Additionally, Japan screens for HTLV-1 antibody due to its endemicity. We also reviewed the protocols for screening and prevention of endemic infections in Asia. Singapore is the only country implementing universal screening for all donors for dengue, Zika, and chikungunya via blood and urine RT-PCR. Strongyloidiasis screening is not routinely done, although some transplant centers empirically give ivermectin prophylaxis to organ recipients. Tuberculosis screening with a donor questionnaire and chest radiograph is common for deceased donors, and some centers do Interferon Gamma Release Assay test for living donors. We also found a significant gap in the surveillance and reporting of potential DDIs in Asia and the overall incidence of DDIs in Asia is unknown and likely underreported.

CONCLUSION:

The experiences of Singapore, Japan, and Thailand offer valuable insights into current practices and the unmet needs regarding a DDI registry and call for coordinated efforts to address this critical issue in the region.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Transpl Infect Dis Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Transpl Infect Dis Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Dinamarca