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Cell-based therapy in the treatment of musculoskeletal diseases.
Trapana, Justin; Weinerman, Jonathan; Lee, Danny; Sedani, Anil; Constantinescu, David; Best, Thomas M; Hornicek, Francis J; Hare, Joshua M.
Afiliación
  • Trapana J; Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, United States.
  • Weinerman J; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, United States.
  • Lee D; Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, United States.
  • Sedani A; Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, United States.
  • Constantinescu D; Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, United States.
  • Best TM; Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, United States.
  • Hornicek FJ; Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, United States.
  • Hare JM; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, United States.
Stem Cells Transl Med ; 13(10): 959-978, 2024 Oct 10.
Article en En | MEDLINE | ID: mdl-39226104
ABSTRACT
A limited number of tissues can spontaneously regenerate following injury, and even fewer can regenerate to a state comparable to mature, healthy adult tissue. Mesenchymal stem cells (MSCs) were first described in the 1960s-1970s by Friedenstein et al as a small population of bone marrow cells with osteogenic potential and abilities to differentiate into chondrocytes. In 1991, Arnold Caplan coined the term "mesenchymal cells" after identifying these cells as a theoretical precursor to bone, cartilage, tendon, ligament, marrow stroma, adipocyte, dermis, muscle, and connective tissues. MSCs are derived from periosteum, fat, and muscle. Another attractive property of MSCs is their immunoregulatory and regenerative properties, which result from crosstalk with their microenvironment and components of the innate immune system. Collectively, these properties make MSCs potentially attractive for various therapeutic purposes. MSCs offer potential in sports medicine, aiding in muscle recovery, meniscal tears, and tendon and ligament injuries. In joint disease, MSCs have the potential for chondrogenesis and reversing the effects of osteoarthritis. MSCs have also demonstrated potential application to the treatment of degenerative disc disease of the cervical, thoracic, and lumbar spine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Musculoesqueléticas / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas Límite: Animals / Humans Idioma: En Revista: Stem Cells Transl Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Musculoesqueléticas / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas Límite: Animals / Humans Idioma: En Revista: Stem Cells Transl Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido