Electrochemically Driven Denitrative Cyanation of Nitroarenes.

Chen, Yiyi; Chen, Qisheng; Zhang, Shuangquan; Feng, Kun; Xu, Yuan-Qing; Chen, Xiaohui; Cao, Zhong-Yan; Kong, Xianqiang

Chen, Yiyi; Chen, Qisheng; Zhang, Shuangquan; Feng, Kun; Xu, Yuan-Qing; Chen, Xiaohui; Cao, Zhong-Yan; Kong, Xianqiang.

Afiliación

Chen Y; School of Chemical Engineering and Materials, Changzhou Institute of Technology, No. 666 Liaohe Road, Changzhou 213032, China.
Chen Q; School of Chemical Engineering and Materials, Changzhou Institute of Technology, No. 666 Liaohe Road, Changzhou 213032, China.
Zhang S; School of Chemical Engineering and Materials, Changzhou Institute of Technology, No. 666 Liaohe Road, Changzhou 213032, China.
Feng K; School of Chemical Engineering and Materials, Changzhou Institute of Technology, No. 666 Liaohe Road, Changzhou 213032, China.
Xu YQ; College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China.
Chen X; School of Chemical Engineering and Materials, Changzhou Institute of Technology, No. 666 Liaohe Road, Changzhou 213032, China.
Cao ZY; College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China.
Kong X; School of Chemical Engineering and Materials, Changzhou Institute of Technology, No. 666 Liaohe Road, Changzhou 213032, China.

Org Lett ; 26(36): 7555-7559, 2024 Sep 13.

Article en En | MEDLINE | ID: mdl-39226075

ABSTRACT

ABSTRACT

A practical denitrative cyanation of feedstock nitroarenes under mild and transition metal-free reaction conditions has been developed. The key to success lies in the use of electrochemically driven, inexpensive ionic liquid N-methylimidazolium p-toluenesulfonate-promoted selective cathode reduction of nitroarenes to anilines, followed by diazoation, cathode reduction to form the aryl radical, and the essential radical cyanation process in one pot. Our protocol shows broad functional group tolerance and can be applied for the modification of bioactive targets.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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