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Comparing 3D imaging devices for the measurement of cutaneous neurofibromas in patients with Neurofibromatosis Type 1.
Lau, Jonathan C L; Fleming, Jane; Good, Martin; Lim, Adrian; Saunderson, Rebecca B; Phan, Tai A; Schlub, Timothy; Siow, Sue-Faye; Lacson, Nanette; Romo, Carlos; Blakely, Jaishri; Bergqvist, Christina; Berman, Yemima D.
Afiliación
  • Lau JCL; Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Fleming J; Department of Clinical Genetics, Royal North Shore Hospital, Sydney, New South Wales, Australia.
  • Good M; Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Lim A; Department of Clinical Genetics, Royal North Shore Hospital, Sydney, New South Wales, Australia.
  • Saunderson RB; Department of Clinical Genetics, Royal North Shore Hospital, Sydney, New South Wales, Australia.
  • Phan TA; Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Schlub T; Department of Dermatology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
  • Siow SF; Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Lacson N; Department of Dermatology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
  • Romo C; Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Blakely J; Department of Dermatology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
  • Bergqvist C; Faculty of Medicine and Health, Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Berman YD; Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Skin Res Technol ; 30(9): e70020, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39225289
ABSTRACT

BACKGROUND:

Cutaneous neurofibromas (cNFs) are a major cause of disfigurement in patients with Neurofibromatosis Type 1 (NF1). However, clinical trials investigating cNF treatments lack standardised outcome measures to objectively evaluate changes in cNF size and appearance. 3D imaging has been proposed as an objective standardised outcome measure however various systems exist with different features that affect useability in clinical settings. The aim of this study was to compare the accuracy, precision, feasibility, reliability and accessibility of three imaging systems. MATERIALS AND

METHODS:

We compared the Vectra-H1, LifeViz-Micro and Cherry-Imaging systems. A total of 58 cNFs from 13 participants with NF1 were selected for imaging and analysis. The primary endpoint was accuracy as measured by comparison of measurements between imaging systems. Secondary endpoints included reliability between two operators, precision as measured with the average coefficient of variation, feasibility as determined by time to capture and analyse an image and accessibility as determined by cost.

RESULTS:

There was no significant difference in accuracy between the three devices for length or surface area measurements (p > 0.05), and reliability and precision were similar. Volume measurements demonstrated the most variability compared to other measurements; LifeViz-Micro demonstrated the least measurement variability for surface area and image capture and analysis were fastest with LifeViz-Micro. LifeViz-Micro was better for imaging smaller number of cNFs (1-3), Vectra-H1 better for larger areas and Cherry for uneven surfaces.

CONCLUSIONS:

All systems demonstrated excellent reliability but possess distinct advantages and limitations. Surface area is the most consistent and reliable parameter for measuring cNF size in clinical trials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Neurofibromatosis 1 / Imagenología Tridimensional Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Skin Res Technol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Neurofibromatosis 1 / Imagenología Tridimensional Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Skin Res Technol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido