Selenium dioxide promoted selenylation/cyclization of leucosceptrane sesterterpenoids.
Chem Commun (Camb)
; 60(76): 10512-10515, 2024 Sep 20.
Article
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| MEDLINE
| ID: mdl-39225283
ABSTRACT
A novel selenium dioxide promoted selenylation/cyclization of leucosceptrane sesterterpenoids was reported. Two types of leucosceptrane derivatives with different valence states of selenium atoms (Se2+ and Se4+) were obtained. The mechanisms of these two processes were proposed, and the selenium-containing derivates may serve as intermediates of Riley oxidation that could be trapped with appropriate substrates. Immunosuppressive activity screening revealed that 10 and 11 had obvious inhibitory effects on IFN-γ production, with IC50 values of 5.29 and 17.60 µM, respectively, which were more active than their precursor leucosceptroid A.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sesterterpenos
/
Óxidos de Selenio
Límite:
Animals
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido