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Are important predictors of adverse outcome in children with symptomatic congenital cytomegalovirus infection overlooked in clinical settings?
Dakovic, Ivana; Kostovic, Ivica; Vulin, Katarina; Prvcic, Iva; Tesovic, Goran; Krakar, Goran; Gojmerac, Tomislav; Sekelj Fures, Jadranka; Mejaski Bosnjak, Vlatka.
Afiliación
  • Dakovic I; Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
  • Kostovic I; Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.
  • Vulin K; Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
  • Prvcic I; Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
  • Tesovic G; University Hospital for Infectious Diseases "Dr. Fran Mihaljevic", University of Zagreb School of Medicine, Zagreb, Croatia.
  • Krakar G; Polyclinic Dr. Sabol, Zagreb, Croatia.
  • Gojmerac T; Children's Hospital Srebrnjak, Zagreb, Croatia.
  • Sekelj Fures J; Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
  • Mejaski Bosnjak V; Faculty of Medicine, University of Osijek, Osijek, Croatia.
J Int Med Res ; 52(9): 3000605241274226, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39224952
ABSTRACT

OBJECTIVE:

Congenital cytomegalovirus infection (cCMV) is a common, frequently unrecognized cause of childhood disability. The aim of the present study was to determine the symptoms that raise the suspicion of cCMV, define the neurodevelopmental outcomes, and assess their correlations.

METHODS:

This longitudinal observational study comprised 78 children with symptomatic cCMV who underwent neuropediatric follow-up for 4 to 17.9 years.

RESULTS:

Symptoms of central nervous system involvement, hearing/visual impairments, and hepatic involvement were mostly recognized. The average age of disease suspicion was 3.3 months. In terms of outcomes, 10.53% of the children developed complex minor neurological dysfunction and 23.68% developed cerebral palsy. Visual and hearing impairments occurred in 38.16% and 14.47% of patients, respectively. Intellectual disability was present in 30.26% of patients, and epilepsy in 21.05%. Microcephaly and hearing impairment was significantly associated with overall neurodevelopmental outcome. Microcephaly was also associated with poor motor outcomes, hearing impairment, and severe visual impairment. Furthermore, microcephaly and intrauterine growth restriction were significantly associated with poor cognitive outcomes.

CONCLUSION:

Symptoms that raised the suspicion of cCMV-especially microcephaly, hearing impairment, and intrauterine growth restriction-were important parameters that were associated with outcomes; however, their recognition was often insufficient and/or late.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Citomegalovirus Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Int Med Res Año: 2024 Tipo del documento: Article País de afiliación: Croacia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Citomegalovirus Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Int Med Res Año: 2024 Tipo del documento: Article País de afiliación: Croacia Pais de publicación: Reino Unido