FDA-approved drugs containing dimethylamine pharmacophore: a review of the last 50 years.

Bindra, Sandeep; Bose, Kuntal; Thekkantavida, Amrutha Chandran; Grace Thomas Parambi, Della; Alsahli, Tariq G; Pant, Manu; Pappachen, Leena K; Kim, Hoon; Mathew, Bijo

Bindra, Sandeep; Bose, Kuntal; Thekkantavida, Amrutha Chandran; Grace Thomas Parambi, Della; Alsahli, Tariq G; Pant, Manu; Pappachen, Leena K; Kim, Hoon; Mathew, Bijo.

Afiliación

Bindra S; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham Amrita Health Science Campus Kochi 682041 India bijomathew@aims.amrita.edu bijovilaventgu@gmail.com.
Bose K; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham Amrita Health Science Campus Kochi 682041 India bijomathew@aims.amrita.edu bijovilaventgu@gmail.com.
Thekkantavida AC; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham Amrita Health Science Campus Kochi 682041 India bijomathew@aims.amrita.edu bijovilaventgu@gmail.com.
Grace Thomas Parambi D; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University Sakaka Aljouf 72341 Saudi Arabia.
Alsahli TG; Department of Pharmacology, College of Pharmacy, Jouf University Sakaka Aljouf 72341 Saudi Arabia.
Pant M; School of Pharmacy, Graphic Era Hill University Dehradun 248002 India.
Pappachen LK; Graphic Era Hill University (Deemed to be University) Clement Town Dehradun 248002 India.
Kim H; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham Amrita Health Science Campus Kochi 682041 India bijomathew@aims.amrita.edu bijovilaventgu@gmail.com.
Mathew B; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University Suncheon 57922 Republic of Korea hoon@sunchon.ac.kr.

RSC Adv ; 14(38): 27657-27696, 2024 Aug 29.

Article en En | MEDLINE | ID: mdl-39224646

ABSTRACT

ABSTRACT

Dimethylamine (DMA) derivatives represent a promising class of compounds with significant potential in the field of medicinal chemistry. DMA derivatives exhibit a diverse range of pharmacological activities, including antimicrobial, antihistaminic, anticancer, and analgesic properties. Their unique chemical structure allows for the modulation of various biological targets, making them valuable candidates for the treatment of numerous diseases. Synthetic strategies for the preparation of DMA derivatives vary depending on the desired biological activity and target molecule. Common synthetic routes involve the modification of the DMA scaffold through functional group manipulation, scaffold hopping, or combinatorial chemistry approaches. Therapeutically, DMA derivatives have shown promise in the treatment of infectious diseases, especially bacterial infections. Additionally, by focusing on particular biochemical pathways involved in tumor growth and metastasis, DMA-based drugs have shown anticancer activity. In addition to their direct pharmacological effects, DMA derivatives can serve as valuable tools in drug delivery systems, prodrug design, and molecular imaging techniques, enhancing their utility in medicinal chemistry research. Overall, DMA derivatives represent a versatile class of compounds with immense potential in medicinal chemistry. Further research and development efforts are warranted to explore their full therapeutic capabilities and optimize their clinical utility in the treatment of various diseases. This article outlines the pharmacological properties, synthetic strategies, and therapeutic applications of DMA derivatives of FDA approved drugs, highlighting their importance in drug discovery and development.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

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