[Research progress on the role of pyroptosis in sepsis-related coagulation disorder].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
; 36(7): 768-773, 2024 Jul.
Article
en Zh
| MEDLINE
| ID: mdl-39223895
ABSTRACT
Sepsis is a common and severe infectious disease, and its associated coagulation dysfunction can cause disseminated intravascular coagulation (DIC) and organ failure, leading to a significant increase in mortality. Pyroptosis is a form of programmed cell death mediated by caspase-1 in the classical pathway and caspase-4/caspase-5/caspase-11 in the non-classical pathway, along with the effector molecule gasdermin (GSDM) family. Recent studies have shown that pyroptosis plays an important role in the development of coagulation disorders in sepsis. Pyroptosis leads to the formation of cytoplasmic membrane pores, cell swelling and membrane rupture, as well as the release and enhanced activity of procoagulant contents, strongly promoting the development of systemic coagulation activation and DIC in sepsis. Therefore, exploring the role and molecular mechanisms of pyroptosis in sepsis-related coagulation disorders is of great significance for the prevention and treatment of sepsis. This article provides a review of the mechanisms involved in pyroptosis and coagulation disorders in sepsis, as well as the role and mechanisms of pyroptosis in sepsis-associated coagulation disorders to provide new ideas for sepsis related research.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos de la Coagulación Sanguínea
/
Sepsis
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Coagulación Intravascular Diseminada
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Piroptosis
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Año:
2024
Tipo del documento:
Article
Pais de publicación:
China