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The protective effect of Ghrelin peptide on doxorubicin hydrochloride induced heart failure in rats.
Peng, Ying; Zhang, Ping; Zou, Pengtao; Zhou, Yuxuan; Shao, Liang.
Afiliación
  • Peng Y; Department of Cardiology, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, Jiangxi Province, China.
  • Zhang P; Department of Neurology, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, Jiangxi Province, China.
  • Zou P; Department of Cardiology, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, Jiangxi Province, China.
  • Zhou Y; Department of Cardiology, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, Jiangxi Province, China.
  • Shao L; Department of Cardiology, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, Jiangxi Province, China. shaoliang5201@126.com.
J Cardiothorac Surg ; 19(1): 508, 2024 Sep 02.
Article en En | MEDLINE | ID: mdl-39223636
ABSTRACT

BACKGROUND:

To investigate the protective effect and mechanism of Ghrelin on Doxorubicin (Dox) hydrochloride induced heart failure (HF) and myocardial injury in rats.

METHODS:

45 rats were randomly divided into control group, HF group and Ghrelin group. Dox hydrochloride was injected intraperitoneally to establish the model of HF in rats of HF group and Ghrelin group. Rats in the Ghrelin group were given intraperitoneal injection of Ghrelin twice a day, and rats in the HF group and control group were given equal volume of normal saline for a total of 6 weeks. The changes of echocardiography, cardiac hemodynamics, myocardial histology and plasma inflammatory factors were observed.

RESULTS:

After the Ghrelin intervention, compared with the HF group, the left ventricular end-diastolic diameter (LVDD) and left ventricular end-systolic diameter (LVSD) in the Ghrelin group was markedly reduced (P < 0.05), and left ventricular ejection fraction (LVEF) was significantly increased (P < 0.05). Compared with HF group, the left ventricular systolic pressure (LVSP), maximum rate of increase in left ventricular pressure (+ dP/dtmax) and maximum rate of decrease in left ventricular pressure (- dP/dtmax) of Ghrelin group was remarkedly increased (P < 0.05), left ventricular diastolic pressure (LVDP) decreased (P < 0.05). In the Ghrelin group, the degree and extent of cardiomyocyte degeneration and necrosis were remarkedly reduced compared with the HF group. The levels of TNF-α and iNOS in Ghrelin group were notably lower than those in HF group (P < 0.05), the IL-10 level increased markedly (P < 0.05).

CONCLUSION:

Ghrelin may reduce Dox-induced myocardial injury and improve cardiac function in rats by regulating inflammation and oxidative stress.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Ratas Sprague-Dawley / Modelos Animales de Enfermedad / Ghrelina / Insuficiencia Cardíaca Límite: Animals Idioma: En Revista: J Cardiothorac Surg Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Ratas Sprague-Dawley / Modelos Animales de Enfermedad / Ghrelina / Insuficiencia Cardíaca Límite: Animals Idioma: En Revista: J Cardiothorac Surg Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido