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Light-emitting diode irradiation at 590 nm combined with active substances modulates ultraviolet B radiation-induced keratinocyte inflammation.
Qin, Yumei; Jiang, Boyang; Yuan, Chunfen; Cui, Lei; Lu, Ming; Zheng, Xia; Yu, Minmin.
Afiliación
  • Qin Y; Flossom Research Laboratories, 2601 Yingfeng Center, 3378 Binhai Avenue, Yuehai Street, Shenzhen, Guangdong, China.
  • Jiang B; Flossom Research Laboratories, 2601 Yingfeng Center, 3378 Binhai Avenue, Yuehai Street, Shenzhen, Guangdong, China. dr.j@flossom.com.
  • Yuan C; Shenzhen Rawskin Dermatology, Shenzhen, China. dr.j@flossom.com.
  • Cui L; Flossom Research Laboratories, 2601 Yingfeng Center, 3378 Binhai Avenue, Yuehai Street, Shenzhen, Guangdong, China.
  • Lu M; , 22/F, Yingfeng Business Center, No.8 Yixing Road, Junlan Community, Beijiao Town, Shunde District, Foshan City, Guangdong, China.
  • Zheng X; , 702, Building B, Hongqiao International Business Plaza, 2679 Hechuan Road, Minhang District, Shanghai, China.
  • Yu M; , 702, Building B, Hongqiao International Business Plaza, 2679 Hechuan Road, Minhang District, Shanghai, China.
Lasers Med Sci ; 39(1): 231, 2024 Sep 03.
Article en En | MEDLINE | ID: mdl-39223344
ABSTRACT
To evaluate the efficacy of yellow light-emitting diode (LED) irradiation at 590 nm, alone or in combination with anti-inflammatory active substances against ultraviolet (UV)-induced inflammation in keratinocytes. HaCaT keratinocytes were pretreated with LED yellow light (590 nm) alone or in combination with an antiinflammatory active substance such as glycerophosphoinositol choline (GC), extract of grains of paradise (Aframomum melegueta Schum, AM), or a bisabolol and ginger root extract mixture (Bb-GE) before UVB irradiation. Following each treatment, we measured the levels of inflammatory mediators secreted by keratinocytes. HaCaT keratinocytes treated with UVB (300 mJ cm-²) and then cultured for 24 h exhibited significantly upregulated expression of proinflammatory factors, including interleukin (IL)-1α, prostaglandin E2 (PGE2), and IL-8. After pretreatment with 590 nm LED, UVB-induced inflammatory responses were significantly inhibited. Co-pretreatment with 590 nm LED irradiation and GC further inhibited the expression of IL-1α and IL-8. IL-8 expression was inhibited by co-pretreatment with 590 nm LED irradiation and AM, whereas PGE2 expression was inhibited by co-pretreatment with 590 nm LED irradiation and Bb-GE. Co-treatment with 590 nm LED irradiation and various active substances modulated UVB-induced inflammation in keratinocytes, suggesting the potential application of this approach to prevent damage caused by voluntary sun exposure in daily life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rayos Ultravioleta / Queratinocitos / Interleucina-8 / Inflamación Límite: Humans Idioma: En Revista: Lasers Med Sci Asunto de la revista: BIOTECNOLOGIA / RADIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rayos Ultravioleta / Queratinocitos / Interleucina-8 / Inflamación Límite: Humans Idioma: En Revista: Lasers Med Sci Asunto de la revista: BIOTECNOLOGIA / RADIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido